Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. - Stepan AF; Claffey MM; Reese MR; Balan G; Barreiro G; Barricklow J; Bohanon MJ; Boscoe BP; Cappon GD; Chenard LK; Cianfrogna J; Chen L; et al. (Journal of medicinal chemistry, 2017)