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A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.

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Title: A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.
Authors: Ramsden CE; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA. chris.ramsden@nih.gov.; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20814, USA.; Department of Physical Medicine and Rehabilitation, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA., Domenichiello AF; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Yuan ZX; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA., Sapio MR; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA., Keyes GS; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA., Mishra SK; Department of Molecular Biomedical Sciences, NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA., Gross JR; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA., Majchrzak-Hong S; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20814, USA., Zamora D; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA., Horowitz MS; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA., Davis JM; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.; Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA., Sorokin AV; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA., Dey A; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA., LaPaglia DM; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA., Wheeler JJ; Department of Molecular Biomedical Sciences, NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA., Vasko MR; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Mehta NN; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA., Mannes AJ; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA., Iadarola MJ; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.
Source: Science signaling [Sci Signal] 2017 Aug 22; Vol. 10 (493). Date of Electronic Publication: 2017 Aug 22.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ramsden+CE%22">Ramsden CE</searchLink>; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA. chris.ramsden@nih.gov.; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20814, USA.; Department of Physical Medicine and Rehabilitation, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.<br /><searchLink fieldCode="AU" term="%22Domenichiello+AF%22">Domenichiello AF</searchLink>; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+ZX%22">Yuan ZX</searchLink>; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Sapio+MR%22">Sapio MR</searchLink>; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Keyes+GS%22">Keyes GS</searchLink>; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Mishra+SK%22">Mishra SK</searchLink>; Department of Molecular Biomedical Sciences, NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.<br /><searchLink fieldCode="AU" term="%22Gross+JR%22">Gross JR</searchLink>; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Majchrzak-Hong+S%22">Majchrzak-Hong S</searchLink>; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Zamora+D%22">Zamora D</searchLink>; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.<br /><searchLink fieldCode="AU" term="%22Horowitz+MS%22">Horowitz MS</searchLink>; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Davis+JM%22">Davis JM</searchLink>; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.; Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.<br /><searchLink fieldCode="AU" term="%22Sorokin+AV%22">Sorokin AV</searchLink>; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Dey+A%22">Dey A</searchLink>; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22LaPaglia+DM%22">LaPaglia DM</searchLink>; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Wheeler+JJ%22">Wheeler JJ</searchLink>; Department of Molecular Biomedical Sciences, NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.<br /><searchLink fieldCode="AU" term="%22Vasko+MR%22">Vasko MR</searchLink>; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+NN%22">Mehta NN</searchLink>; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Mannes+AJ%22">Mannes AJ</searchLink>; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Iadarola+MJ%22">Iadarola MJ</searchLink>; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.
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