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Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: data from 10 phase I trials.

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Title: Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: data from 10 phase I trials.
Authors: Patel P; Manchester Pharmacy School, Manchester, UK., Howgate E; Manchester Pharmacy School, Manchester, UK., Martin P; AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK., Carlile DJ; AstraZeneca, Early Clinical Development, Innovative Medicines and Early Development Biotech Unit, Da Vinci Building, Royston, Hertfordshire, UK., Aarons L; Manchester Pharmacy School, Manchester, UK., Zhou D; AstraZeneca, Waltham, MA, USA.
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2018 Jan; Vol. 84 (1), pp. 52-63. Date of Electronic Publication: 2017 Sep 22.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: data from 10 phase I trials.
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  Data: <searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; Manchester Pharmacy School, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Howgate+E%22">Howgate E</searchLink>; Manchester Pharmacy School, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Martin+P%22">Martin P</searchLink>; AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK.<br /><searchLink fieldCode="AU" term="%22Carlile+DJ%22">Carlile DJ</searchLink>; AstraZeneca, Early Clinical Development, Innovative Medicines and Early Development Biotech Unit, Da Vinci Building, Royston, Hertfordshire, UK.<br /><searchLink fieldCode="AU" term="%22Aarons+L%22">Aarons L</searchLink>; Manchester Pharmacy School, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Zhou+D%22">Zhou D</searchLink>; AstraZeneca, Waltham, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%227503323%22">British journal of clinical pharmacology</searchLink> [Br J Clin Pharmacol] 2018 Jan; Vol. 84 (1), pp. 52-63. <i>Date of Electronic Publication: </i>2017 Sep 22.
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        Value: 10.1111/bcp.13404
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