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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).

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Title: Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
Authors: Huard K; Medicine Design, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Ahn K; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Amor P; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Beebe DA; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Borzilleri KA; Structural Biology and Biophysics, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Chrunyk BA; Structural Biology and Biophysics, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Coffey SB; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Cong Y; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Conn EL; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Culp JS; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Dowling MS; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Gorgoglione MF; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Gutierrez JA; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Knafels JD; Structural Biology and Biophysics, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Lachapelle EA; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Pandit J; Structural Biology and Biophysics, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Parris KD; Structural Biology and Biophysics, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Perez S; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Pfefferkorn JA; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Price DA; Medicine Design, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Raymer B; Medicine Design, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Ross TT; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Shavnya A; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Smith AC; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Subashi TA; Structural Biology and Biophysics, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Tesz GJ; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Thuma BA; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Tu M; Medicine Design, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Weaver JD; Medicine Design, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Weng Y; Medicine Design, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Withka JM; Structural Biology and Biophysics, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Xing G; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Magee TV; Internal Medicine, Pfizer Inc. , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Sep 28; Vol. 60 (18), pp. 7835-7849. Date of Electronic Publication: 2017 Sep 11.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2017 Sep 28; Vol. 60 (18), pp. 7835-7849. <i>Date of Electronic Publication: </i>2017 Sep 11.
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        Value: 10.1021/acs.jmedchem.7b00947
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