In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels.
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| Title: | In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. |
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| Authors: | Cherry JJ; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., DiDonato CJ; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Human Molecular Genetics Program, Ann & Robert Lurie Children's Hospital, Stanley Manne Research Institute, Chicago, Illinois, United States of America., Androphy EJ; Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Calo A; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Potter K; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Human Molecular Genetics Program, Ann & Robert Lurie Children's Hospital, Stanley Manne Research Institute, Chicago, Illinois, United States of America., Custer SK; Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Du S; Precision Medicine, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Foley TL; Pharmaceutical Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America.; Primary Pharmacology Group, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Gopalsamy A; Medicine Design, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Reedich EJ; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Human Molecular Genetics Program, Ann & Robert Lurie Children's Hospital, Stanley Manne Research Institute, Chicago, Illinois, United States of America., Gordo SM; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Gordon W; Precision Medicine, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Hosea N; Pharmacokinetics and Drug Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Jones LH; Medicine Design, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Krizay DK; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., LaRosa G; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Li H; Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Mathur S; Business Technology, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Menard CA; Pharmaceutical Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America.; Primary Pharmacology Group, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Patel P; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Ramos-Zayas R; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Rietz A; Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Rong H; Pharmacokinetics and Drug Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Zhang B; Clinical Genetics, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Tones MA; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America. |
| Source: | PloS one [PLoS One] 2017 Sep 25; Vol. 12 (9), pp. e0185079. Date of Electronic Publication: 2017 Sep 25 (Print Publication: 2017). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 28945765 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Cherry+JJ%22">Cherry JJ</searchLink>; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22DiDonato+CJ%22">DiDonato CJ</searchLink>; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Human Molecular Genetics Program, Ann & Robert Lurie Children's Hospital, Stanley Manne Research Institute, Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Androphy+EJ%22">Androphy EJ</searchLink>; Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Calo+A%22">Calo A</searchLink>; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Potter+K%22">Potter K</searchLink>; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Human Molecular Genetics Program, Ann & Robert Lurie Children's Hospital, Stanley Manne Research Institute, Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Custer+SK%22">Custer SK</searchLink>; Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Du+S%22">Du S</searchLink>; Precision Medicine, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Foley+TL%22">Foley TL</searchLink>; Pharmaceutical Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America.; Primary Pharmacology Group, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Gopalsamy+A%22">Gopalsamy A</searchLink>; Medicine Design, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Reedich+EJ%22">Reedich EJ</searchLink>; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Human Molecular Genetics Program, Ann & Robert Lurie Children's Hospital, Stanley Manne Research Institute, Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Gordo+SM%22">Gordo SM</searchLink>; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Gordon+W%22">Gordon W</searchLink>; Precision Medicine, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Hosea+N%22">Hosea N</searchLink>; Pharmacokinetics and Drug Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Jones+LH%22">Jones LH</searchLink>; Medicine Design, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Krizay+DK%22">Krizay DK</searchLink>; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22LaRosa+G%22">LaRosa G</searchLink>; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Mathur+S%22">Mathur S</searchLink>; Business Technology, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Menard+CA%22">Menard CA</searchLink>; Pharmaceutical Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America.; Primary Pharmacology Group, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Ramos-Zayas+R%22">Ramos-Zayas R</searchLink>; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Rietz+A%22">Rietz A</searchLink>; Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Rong+H%22">Rong H</searchLink>; Pharmacokinetics and Drug Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Clinical Genetics, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Tones+MA%22">Tones MA</searchLink>; Rare Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2017 Sep 25; Vol. 12 (9), pp. e0185079. <i>Date of Electronic Publication: </i>2017 Sep 25 (<i>Print Publication: </i>2017). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101285081 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-6203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219326203%22">19326203 </searchLink><i>NLM ISO Abbreviation: </i>PLoS One <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=28945765 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0185079 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e0185079 Titles: – TitleFull: In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cherry JJ – PersonEntity: Name: NameFull: DiDonato CJ – PersonEntity: Name: NameFull: Androphy EJ – PersonEntity: Name: NameFull: Calo A – PersonEntity: Name: NameFull: Potter K – PersonEntity: Name: NameFull: Custer SK – PersonEntity: Name: NameFull: Du S – PersonEntity: Name: NameFull: Foley TL – PersonEntity: Name: NameFull: Gopalsamy A – PersonEntity: Name: NameFull: Reedich EJ – PersonEntity: Name: NameFull: Gordo SM – PersonEntity: Name: NameFull: Gordon W – PersonEntity: Name: NameFull: Hosea N – PersonEntity: Name: NameFull: Jones LH – PersonEntity: Name: NameFull: Krizay DK – PersonEntity: Name: NameFull: LaRosa G – PersonEntity: Name: NameFull: Li H – PersonEntity: Name: NameFull: Mathur S – PersonEntity: Name: NameFull: Menard CA – PersonEntity: Name: NameFull: Patel P – PersonEntity: Name: NameFull: Ramos-Zayas R – PersonEntity: Name: NameFull: Rietz A – PersonEntity: Name: NameFull: Rong H – PersonEntity: Name: NameFull: Zhang B – PersonEntity: Name: NameFull: Tones MA IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 09 Text: 2017 Sep 25 Type: published Y: 2017 Identifiers: – Type: issn-electronic Value: 1932-6203 Numbering: – Type: volume Value: 12 – Type: issue Value: 9 Titles: – TitleFull: PloS one Type: main |
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