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Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.

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Title: Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.
Authors: Dand N; Division of Genetics and Molecular Medicine, Faculty of Life Sciences & Medicine, King's College London, London, UK., Mucha S; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Tsoi LC; Department of Dermatology.; Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Mahil SK; St John's Institute of Dermatology, Faculty of Life Sciences & Medicine, King's College London, London, UK., Stuart PE; Department of Dermatology., Arnold A; Clinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany., Baurecht H; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Burden AD; Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK., Callis Duffin K; Department of Dermatology, University of Utah, Salt Lake City, UT, USA., Chandran V; Department of Medicine.; Department of Laboratory Medicine and Pathobiology.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Krembil Research Institute, University Health Network, Toronto, ON, Canada., Curtis CJ; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Das S; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Ellinghaus E; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Enerback C; Division of Cell Biology and Dermatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden., Esko T; Estonian Biobank, Estonian Genome Center, University of Tartu, Tartu, Estonia., Gladman DD; Department of Medicine.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Krembil Research Institute, University Health Network, Toronto, ON, Canada., Griffiths CEM; Dermatology Centre, Salford Royal Hospital, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Gudjonsson JE; Department of Dermatology., Hoffman P; Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Human Genetics, University of Bonn, Bonn, Germany., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany., Hüffmeier U; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Krueger GG; Department of Dermatology, University of Utah, Salt Lake City, UT, USA., Laudes M; I. Department of Medicine., Lee SH; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Lieb W; Institute of Epidemiology and Biobank PopGen, Christian-Albrechts-University of Kiel, Kiel, Germany., Lim HW; Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA., Löhr S; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Mrowietz U; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Müller-Nurayid M; Institute of Genetic Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany., Nöthen M; Institute of Human Genetics, University of Bonn, Bonn, Germany., Peters A; Institute of Genetic Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany., Rahman P; Memorial University of Newfoundland, St. John's, NL, Canada., Reis A; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Reynolds NJ; Dermatological Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK.; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Rodriguez E; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Schmidt CO; Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany., Spain SL; Division of Genetics and Molecular Medicine, Faculty of Life Sciences & Medicine, King's College London, London, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany., Tejasvi T; Department of Dermatology., Voorhees JJ; Department of Dermatology., Warren RB; Dermatology Centre, Salford Road NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK., Weichenthal M; Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany., Weidinger S; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Zawistowski M; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Nair RP; Department of Dermatology., Capon F; Division of Genetics and Molecular Medicine, Faculty of Life Sciences & Medicine, King's College London, London, UK., Smith CH; St John's Institute of Dermatology, Faculty of Life Sciences & Medicine, King's College London, London, UK., Trembath RC; Division of Genetics and Molecular Medicine, Faculty of Life Sciences & Medicine, King's College London, London, UK., Abecasis GR; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Elder JT; Department of Dermatology.; Ann Arbor Veterans Hospital, Ann Arbor, MI, USA., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Simpson MA; Division of Genetics and Molecular Medicine, Faculty of Life Sciences & Medicine, King's College London, London, UK., Barker JN; St John's Institute of Dermatology, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Source: Human molecular genetics [Hum Mol Genet] 2017 Nov 01; Vol. 26 (21), pp. 4301-4313.
Publication Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.
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          Dates:
            – D: 01
              M: 11
              Text: 2017 Nov 01
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-electronic
              Value: 1460-2083
          Numbering:
            – Type: volume
              Value: 26
            – Type: issue
              Value: 21
          Titles:
            – TitleFull: Human molecular genetics
              Type: main
ResultId 1