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Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.

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Title: Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.
Authors: Burlein C; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Wang C; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Xu M; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Bhatt T; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Stahlhut M; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Ou Y; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Adam GC; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Heath J; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Klein DJ; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Sanders J; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Narayan K; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Abeywickrema P; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Heo MR; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Carroll SS; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Grobler JA; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Sharma S; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Diamond TL; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Converso A; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Krosky DJ; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
Source: ACS chemical biology [ACS Chem Biol] 2017 Nov 17; Vol. 12 (11), pp. 2858-2865. Date of Electronic Publication: 2017 Oct 19.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
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  Data: Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.
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  Data: <searchLink fieldCode="AU" term="%22Burlein+C%22">Burlein C</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Bhatt+T%22">Bhatt T</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Stahlhut+M%22">Stahlhut M</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Ou+Y%22">Ou Y</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Adam+GC%22">Adam GC</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Heath+J%22">Heath J</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Klein+DJ%22">Klein DJ</searchLink>; 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Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Carroll+SS%22">Carroll SS</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Grobler+JA%22">Grobler JA</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Diamond+TL%22">Diamond TL</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%22101282906%22">ACS chemical biology</searchLink> [ACS Chem Biol] 2017 Nov 17; Vol. 12 (11), pp. 2858-2865. <i>Date of Electronic Publication: </i>2017 Oct 19.
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