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Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.

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Title: Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.
Authors: Noh HJ; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. noh@broadinstitute.org., Tang R; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.; Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA, 02139, USA.; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Shandong Middle Road, Huangpu Qu, Shanghai, 200001, China., Flannick J; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., O'Dushlaine C; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Swofford R; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Howrigan D; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Genereux DP; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Johnson J; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., van Grootheest G; GGZ inGeest and Department of Psychiatry, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Grünblatt E; Department of Child & Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Neumünsterallee 9, Zurich, 8032, Switzerland.; Neuroscience Center Zurich, University of Zurich & ETH Zurich, Winterthurer Strasse 190, Zurich, 8057, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurer Strasse 190, Zurich, 8057, Switzerland., Andersson E; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden., Djurfeldt DR; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, 14186, Sweden., Patel PD; Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA., Koltookian M; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., M Hultman C; Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden., Pato MT; Department of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA., Pato CN; Department of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA., Rasmussen SA; Department of Psychiatry & Human Behavior, Brown Medical School, 345 Blackstone Boulevard, Box G-BH, Providence, RI, 02906, USA., Jenike MA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA, 02215, USA., Hanna GL; Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA., Stewart SE; BC Mental Health & Addictions Research Institute, UBC, 2255 Wesbrook Mall, Vancouver, BC, Canada, V6T 2A1., Knowles JA; Department of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA., Ruhrmann S; Department of Psychiatry & Psychotherapy, University of Cologne, Kerpener Street 62, Cologne, 50937, Germany., Grabe HJ; Department of Psychiatry & Psychotherapy, University of Medicine Greifswald, Fleischmannstrasse 8, Greifswald, 17475, Germany., Wagner M; Department of Psychiatry & Psychotherapy, University of Bonn, Regina-Pacis-Weg 3, Bonn, 53113, Germany.; German Center for Neurodegenerative Diseases, Sigmund-Freud-Strasse 27, Bonn, 53127, Germany., Rück C; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, 14186, Sweden., Mathews CA; Department of Psychiatry & Genetics Institute, University of Florida, 1149 Newell Drive, Gainesville, FL, 32610, USA., Walitza S; Department of Child & Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Neumünsterallee 9, Zurich, 8032, Switzerland.; Neuroscience Center Zurich, University of Zurich & ETH Zurich, Winterthurer Strasse 190, Zurich, 8057, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurer Strasse 190, Zurich, 8057, Switzerland., Cath DC; Department of Clinical & Health Psychology, Utrecht University, Heidelberglaan 1, Utrecht, CS, 3584, The Netherlands., Feng G; Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA, 02139, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Karlsson EK; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. elinor@broadinstitute.org.; Program in Bioinformatics & Integrative Biology and Program in Molecular Medicine, University of Massachusetts Medical School, 368 Plantation Street, Sherman Center, Worcester, MA, 01605, USA. elinor@broadinstitute.org., Lindblad-Toh K; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. kersli@broadinstitute.org.; Science for Life Laboratory, IMBIM, Uppsala University, Uppsala, 75236, Sweden. kersli@broadinstitute.org.
Source: Nature communications [Nat Commun] 2017 Oct 17; Vol. 8 (1), pp. 774. Date of Electronic Publication: 2017 Oct 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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Neuroscience Center Zurich, University of Zurich & ETH Zurich, Winterthurer Strasse 190, Zurich, 8057, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurer Strasse 190, Zurich, 8057, Switzerland.<br /><searchLink fieldCode="AU" term="%22Andersson+E%22">Andersson E</searchLink>; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.<br /><searchLink fieldCode="AU" term="%22Djurfeldt+DR%22">Djurfeldt DR</searchLink>; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, 14186, Sweden.<br /><searchLink fieldCode="AU" term="%22Patel+PD%22">Patel PD</searchLink>; Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Koltookian+M%22">Koltookian M</searchLink>; 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