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Resistance to checkpoint blockade therapy through inactivation of antigen presentation.

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Title: Resistance to checkpoint blockade therapy through inactivation of antigen presentation.
Authors: Sade-Feldman M; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA., Jiao YJ; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA.; Department Systems Biology, Harvard Medical School, Boston, MA, 02115, USA., Chen JH; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA., Rooney MS; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA., Barzily-Rokni M; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Eliane JP; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA., Bjorgaard SL; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA., Hammond MR; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Vitzthum H; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Blackmon SM; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Frederick DT; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Hazar-Rethinam M; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Nadres BA; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Van Seventer EE; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Shukla SA; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Yizhak K; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA., Ray JP; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA., Rosebrock D; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA., Livitz D; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA., Adalsteinsson V; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA., Getz G; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA., Duncan LM; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA., Li B; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Corcoran RB; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Lawrence DP; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Stemmer-Rachamimov A; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA., Boland GM; Department of Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA., Landau DA; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA.; New York Genome Center, NYC, New York, NY, 10013, USA.; Department of Medicine and Department of Physiology and Biophysics, Weill Cornell Medicine, NYC, New York, NY, 10065, USA., Flaherty KT; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA., Sullivan RJ; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA. RSULLIVAN7@mgh.harvard.edu., Hacohen N; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA. NHACOHEN@mgh.harvard.edu.; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA. NHACOHEN@mgh.harvard.edu.
Source: Nature communications [Nat Commun] 2017 Oct 26; Vol. 8 (1), pp. 1136. Date of Electronic Publication: 2017 Oct 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142, USA.; New York Genome Center, NYC, New York, NY, 10013, USA.; Department of Medicine and Department of Physiology and Biophysics, Weill Cornell Medicine, NYC, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Flaherty+KT%22">Flaherty KT</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+RJ%22">Sullivan RJ</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA. 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