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Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

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Title: Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Authors: McClure KF; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Piotrowski DW; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Petersen D; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Wei L; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Xiao J; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Londregan AT; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Kamlet AS; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Dechert-Schmitt AM; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Raymer B; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Ruggeri RB; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Canterbury D; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Limberakis C; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Liras S; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., DaSilva-Jardine P, Dullea RG; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Loria PM; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Reidich B; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Salatto CT; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Eng H; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Kimoto E; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Atkinson K; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., King-Ahmad A; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Scott D; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Beaumont K; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Chabot JR; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Bolt MW; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Maresca K; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA., Dahl K; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden., Arakawa R; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden., Takano A; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden., Halldin C; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Dec 18; Vol. 56 (51), pp. 16218-16222. Date of Electronic Publication: 2017 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
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Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Atkinson+K%22">Atkinson K</searchLink>; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22King-Ahmad+A%22">King-Ahmad A</searchLink>; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Scott+D%22">Scott D</searchLink>; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Beaumont+K%22">Beaumont K</searchLink>; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Chabot+JR%22">Chabot JR</searchLink>; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Bolt+MW%22">Bolt MW</searchLink>; 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