Lower cardiac index levels relate to lower cerebral blood flow in older adults.

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Title: Lower cardiac index levels relate to lower cerebral blood flow in older adults.
Authors: Jefferson AL; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle. angela.jefferson@vanderbilt.edu., Liu D; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Gupta DK; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Pechman KR; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Watchmaker JM; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Gordon EA; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Rane S; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Bell SP; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Mendes LA; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Davis LT; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Gifford KA; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Hohman TJ; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Wang TJ; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle., Donahue MJ; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.
Source: Neurology [Neurology] 2017 Dec 05; Vol. 89 (23), pp. 2327-2334. Date of Electronic Publication: 2017 Nov 08.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE
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  Data: Lower cardiac index levels relate to lower cerebral blood flow in older adults.
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  Data: <searchLink fieldCode="AU" term="%22Jefferson+AL%22">Jefferson AL</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle. angela.jefferson@vanderbilt.edu.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Gupta+DK%22">Gupta DK</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Pechman+KR%22">Pechman KR</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Watchmaker+JM%22">Watchmaker JM</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Gordon+EA%22">Gordon EA</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Rane+S%22">Rane S</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Bell+SP%22">Bell SP</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Mendes+LA%22">Mendes LA</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Davis+LT%22">Davis LT</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Gifford+KA%22">Gifford KA</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Hohman+TJ%22">Hohman TJ</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Wang+TJ%22">Wang TJ</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.<br /><searchLink fieldCode="AU" term="%22Donahue+MJ%22">Donahue MJ</searchLink>; From the Vanderbilt Memory & Alzheimer's Center (A.L.J., K.R.P., E.A.G., S.P.B., K.A.G., T.J.H., M.J.D.), Department of Neurology, Department of Biostatistics (D.L.), Division of Cardiovascular Medicine (D.K.G., S.P.B., L.A.M., T.J.W.), Department of Medicine, Division of General Internal Medicine, Center for Quality Aging (S.P.B.), Radiology & Radiological Sciences (L.T.D., M.J.D.), and Department of Psychiatry (M.J.D.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (J.M.W., M.J.D.), Nashville, TN; and Radiology (S.R.), University of Washington Medical Center, Seattle.
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