View in EDS

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Saved in:
Bibliographic Details
Title: Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Authors: Rai G; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Brimacombe KR; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Mott BT; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Urban DJ; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Hu X; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Yang SM; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Lee TD; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Cheff DM; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Kouznetsova J; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Benavides GA; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham , Birmingham, Alabama 35294, United States., Pohida K; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Kuenstner EJ; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Luci DK; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Lukacs CM; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States., Davies DR; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States., Dranow DM; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States., Zhu H; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Sulikowski G; Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37232, United States., Moore WJ; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States., Stott GM; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States., Flint AJ; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States., Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Darley-Usmar VM; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham , Birmingham, Alabama 35294, United States., Neckers LM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute , 9000 Rockville Pike, Bethesda, Maryland 20892, United States., Dang CV; Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania , Philadephia, Pennsylvania 19104, United States., Waterson AG; Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37232, United States., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Maloney DJ; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Nov 22; Vol. 60 (22), pp. 9184-9204. Date of Electronic Publication: 2017 Nov 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 29120638
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Rai+G%22">Rai G</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Brimacombe+KR%22">Brimacombe KR</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Mott+BT%22">Mott BT</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Urban+DJ%22">Urban DJ</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Yang+SM%22">Yang SM</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Lee+TD%22">Lee TD</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Cheff+DM%22">Cheff DM</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Kouznetsova+J%22">Kouznetsova J</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Benavides+GA%22">Benavides GA</searchLink>; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham , Birmingham, Alabama 35294, United States.<br /><searchLink fieldCode="AU" term="%22Pohida+K%22">Pohida K</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Kuenstner+EJ%22">Kuenstner EJ</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Luci+DK%22">Luci DK</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Lukacs+CM%22">Lukacs CM</searchLink>; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States.<br /><searchLink fieldCode="AU" term="%22Davies+DR%22">Davies DR</searchLink>; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States.<br /><searchLink fieldCode="AU" term="%22Dranow+DM%22">Dranow DM</searchLink>; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Sulikowski+G%22">Sulikowski G</searchLink>; Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Moore+WJ%22">Moore WJ</searchLink>; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States.<br /><searchLink fieldCode="AU" term="%22Stott+GM%22">Stott GM</searchLink>; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States.<br /><searchLink fieldCode="AU" term="%22Flint+AJ%22">Flint AJ</searchLink>; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States.<br /><searchLink fieldCode="AU" term="%22Hall+MD%22">Hall MD</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Darley-Usmar+VM%22">Darley-Usmar VM</searchLink>; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham , Birmingham, Alabama 35294, United States.<br /><searchLink fieldCode="AU" term="%22Neckers+LM%22">Neckers LM</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute , 9000 Rockville Pike, Bethesda, Maryland 20892, United States.<br /><searchLink fieldCode="AU" term="%22Dang+CV%22">Dang CV</searchLink>; Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania , Philadephia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Waterson+AG%22">Waterson AG</searchLink>; Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Simeonov+A%22">Simeonov A</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Jadhav+A%22">Jadhav A</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Maloney+DJ%22">Maloney DJ</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2017 Nov 22; Vol. 60 (22), pp. 9184-9204. <i>Date of Electronic Publication: </i>2017 Nov 09.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=29120638
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.7b00941
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 9184
    Titles:
      – TitleFull: Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Rai G
      – PersonEntity:
          Name:
            NameFull: Brimacombe KR
      – PersonEntity:
          Name:
            NameFull: Mott BT
      – PersonEntity:
          Name:
            NameFull: Urban DJ
      – PersonEntity:
          Name:
            NameFull: Hu X
      – PersonEntity:
          Name:
            NameFull: Yang SM
      – PersonEntity:
          Name:
            NameFull: Lee TD
      – PersonEntity:
          Name:
            NameFull: Cheff DM
      – PersonEntity:
          Name:
            NameFull: Kouznetsova J
      – PersonEntity:
          Name:
            NameFull: Benavides GA
      – PersonEntity:
          Name:
            NameFull: Pohida K
      – PersonEntity:
          Name:
            NameFull: Kuenstner EJ
      – PersonEntity:
          Name:
            NameFull: Luci DK
      – PersonEntity:
          Name:
            NameFull: Lukacs CM
      – PersonEntity:
          Name:
            NameFull: Davies DR
      – PersonEntity:
          Name:
            NameFull: Dranow DM
      – PersonEntity:
          Name:
            NameFull: Zhu H
      – PersonEntity:
          Name:
            NameFull: Sulikowski G
      – PersonEntity:
          Name:
            NameFull: Moore WJ
      – PersonEntity:
          Name:
            NameFull: Stott GM
      – PersonEntity:
          Name:
            NameFull: Flint AJ
      – PersonEntity:
          Name:
            NameFull: Hall MD
      – PersonEntity:
          Name:
            NameFull: Darley-Usmar VM
      – PersonEntity:
          Name:
            NameFull: Neckers LM
      – PersonEntity:
          Name:
            NameFull: Dang CV
      – PersonEntity:
          Name:
            NameFull: Waterson AG
      – PersonEntity:
          Name:
            NameFull: Simeonov A
      – PersonEntity:
          Name:
            NameFull: Jadhav A
      – PersonEntity:
          Name:
            NameFull: Maloney DJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 22
              M: 11
              Text: 2017 Nov 22
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 60
            – Type: issue
              Value: 22
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1