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A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study.

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Title: A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study.
Authors: Latva-Rasku A; Turku PET Centre, University of Turku, Turku, Finland., Honka MJ; Turku PET Centre, University of Turku, Turku, Finland., Stančáková A; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Koistinen HA; University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kuusisto J; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicine, Kuopio University Hospital, Kuopio, Finland., Guan L; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Manning AK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Stringham H; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Gloyn AL; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K., Collins FS; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Karjalainen T; Turku PET Centre, University of Turku, Turku, Finland., Nummenmaa L; Turku PET Centre, University of Turku, Turku, Finland.; Department of Psychology, University of Turku, Finland., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI markku.laakso@uef.fi pirjo.nuutila@utu.fi boehnke@umich.edu., Nuutila P; Turku PET Centre, University of Turku, Turku, Finland markku.laakso@uef.fi pirjo.nuutila@utu.fi boehnke@umich.edu.; Department of Endocrinology, Turku University Hospital, Turku, Finland., Laakso M; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland markku.laakso@uef.fi pirjo.nuutila@utu.fi boehnke@umich.edu.; Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
Corporate Authors: T2D-GENES Consortium
Source: Diabetes [Diabetes] 2018 Feb; Vol. 67 (2), pp. 334-342. Date of Electronic Publication: 2017 Nov 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
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