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Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity.

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Title: Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity.
Authors: Strege PR; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota., Mazzone A; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota., Bernard CE; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota., Neshatian L; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota., Gibbons SJ; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota., Saito YA; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota., Tester DJ; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota., Calvert ML; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota., Mayer EA; Oppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases, University of California Los Angeles , Los Angeles, California., Chang L; Oppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases, University of California Los Angeles , Los Angeles, California., Ackerman MJ; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota., Beyder A; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota., Farrugia G; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
Source: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2018 Apr 01; Vol. 314 (4), pp. G494-G503. Date of Electronic Publication: 2017 Nov 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1547 (Electronic) Linking ISSN: 01931857 NLM ISO Abbreviation: Am J Physiol Gastrointest Liver Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Na<subscript>V</subscript>1.5 current and mechanosensitivity.
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  Data: <searchLink fieldCode="AU" term="%22Strege+PR%22">Strege PR</searchLink>; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Mazzone+A%22">Mazzone A</searchLink>; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Bernard+CE%22">Bernard CE</searchLink>; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Neshatian+L%22">Neshatian L</searchLink>; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Gibbons+SJ%22">Gibbons SJ</searchLink>; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Saito+YA%22">Saito YA</searchLink>; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Tester+DJ%22">Tester DJ</searchLink>; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Calvert+ML%22">Calvert ML</searchLink>; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Mayer+EA%22">Mayer EA</searchLink>; Oppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases, University of California Los Angeles , Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Chang+L%22">Chang L</searchLink>; Oppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases, University of California Los Angeles , Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Ackerman+MJ%22">Ackerman MJ</searchLink>; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Beyder+A%22">Beyder A</searchLink>; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Farrugia+G%22">Farrugia G</searchLink>; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
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  Data: <searchLink fieldCode="JN" term="%22100901227%22">American journal of physiology. Gastrointestinal and liver physiology</searchLink> [Am J Physiol Gastrointest Liver Physiol] 2018 Apr 01; Vol. 314 (4), pp. G494-G503. <i>Date of Electronic Publication: </i>2017 Nov 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901227 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1547 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201931857%22">01931857 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Gastrointest Liver Physiol <i>Subsets: </i>MEDLINE
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