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Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium.

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Title: Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium.
Authors: Park E; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA., Gintant GA; Department of Integrative Pharmacology, AbbVie, North Chicago, IL, USA., Bi D; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA., Kozeli D; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA., Pettit SD; HESI, Washington, DC, USA., Pierson JB; HESI, Washington, DC, USA., Skinner M; Drug Safety and Metabolism, AstraZeneca, Macclesfield, Cheshire, UK., Willard J; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA., Wisialowski T; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Koerner J; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA., Valentin JP; Non-Clinical Development, UCB-Biopharma SPRL, Braine-l'Alleud, Belgium.
Source: British journal of pharmacology [Br J Pharmacol] 2018 Feb; Vol. 175 (4), pp. 606-617. Date of Electronic Publication: 2018 Jan 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium.
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  Data: <searchLink fieldCode="AU" term="%22Park+E%22">Park E</searchLink>; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gintant+GA%22">Gintant GA</searchLink>; Department of Integrative Pharmacology, AbbVie, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Bi+D%22">Bi D</searchLink>; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kozeli+D%22">Kozeli D</searchLink>; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Pettit+SD%22">Pettit SD</searchLink>; HESI, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Pierson+JB%22">Pierson JB</searchLink>; HESI, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Skinner+M%22">Skinner M</searchLink>; Drug Safety and Metabolism, AstraZeneca, Macclesfield, Cheshire, UK.<br /><searchLink fieldCode="AU" term="%22Willard+J%22">Willard J</searchLink>; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wisialowski+T%22">Wisialowski T</searchLink>; Drug Safety Research and Development, Pfizer, Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Koerner+J%22">Koerner J</searchLink>; Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Valentin+JP%22">Valentin JP</searchLink>; Non-Clinical Development, UCB-Biopharma SPRL, Braine-l'Alleud, Belgium.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2018 Feb; Vol. 175 (4), pp. 606-617. <i>Date of Electronic Publication: </i>2018 Jan 15.
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              Text: 2018 Feb
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