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CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

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Title: CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
Authors: Chen L; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Bioinformatics Graduate Program, Boston University, Boston, Massachusetts, USA., Dharia NV; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Ross L; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA., Iniguez AB; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA., Conway AS; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA., Wang EJ; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA., Veschi V; Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA., Lam N; Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA., Qi J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Gustafson WC; Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA., Nasholm N; Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA., Vazquez F; Broad Institute, Cambridge, Massachusetts, USA., Weir BA; Broad Institute, Cambridge, Massachusetts, USA., Cowley GS; Broad Institute, Cambridge, Massachusetts, USA., Ali LD; Broad Institute, Cambridge, Massachusetts, USA., Pantel S; Broad Institute, Cambridge, Massachusetts, USA., Jiang G; Broad Institute, Cambridge, Massachusetts, USA., Harrington WF; Broad Institute, Cambridge, Massachusetts, USA., Lee Y; Broad Institute, Cambridge, Massachusetts, USA., Goodale A; Broad Institute, Cambridge, Massachusetts, USA., Lubonja R; Broad Institute, Cambridge, Massachusetts, USA., Krill-Burger JM; Broad Institute, Cambridge, Massachusetts, USA., Meyers RM; Broad Institute, Cambridge, Massachusetts, USA., Tsherniak A; Broad Institute, Cambridge, Massachusetts, USA., Root DE; Broad Institute, Cambridge, Massachusetts, USA., Bradner JE; Harvard Medical School, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Golub TR; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Roberts CW; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Comprehensive Cancer Center and Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Hahn WC; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Weiss WA; Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.; Department of Neurology, Neurological Surgery, Brain Tumor Research Center, UCSF, San Francisco, California, USA., Thiele CJ; Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2018 Jan 02; Vol. 128 (1), pp. 446-462. Date of Electronic Publication: 2017 Dec 04.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
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  Data: CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
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  Data: <searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Alexe+G%22">Alexe G</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Bioinformatics Graduate Program, Boston University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Dharia+NV%22">Dharia NV</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ross+L%22">Ross L</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Iniguez+AB%22">Iniguez AB</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Conway+AS%22">Conway AS</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wang+EJ%22">Wang EJ</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Veschi+V%22">Veschi V</searchLink>; Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lam+N%22">Lam N</searchLink>; Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gustafson+WC%22">Gustafson WC</searchLink>; Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Nasholm+N%22">Nasholm N</searchLink>; Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Vazquez+F%22">Vazquez F</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Weir+BA%22">Weir BA</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cowley+GS%22">Cowley GS</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ali+LD%22">Ali LD</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Pantel+S%22">Pantel S</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+G%22">Jiang G</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Harrington+WF%22">Harrington WF</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Goodale+A%22">Goodale A</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lubonja+R%22">Lubonja R</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Krill-Burger+JM%22">Krill-Burger JM</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Meyers+RM%22">Meyers RM</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Tsherniak+A%22">Tsherniak A</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Root+DE%22">Root DE</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bradner+JE%22">Bradner JE</searchLink>; Harvard Medical School, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Golub+TR%22">Golub TR</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+CW%22">Roberts CW</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Comprehensive Cancer Center and Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Hahn+WC%22">Hahn WC</searchLink>; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+WA%22">Weiss WA</searchLink>; Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.; Department of Neurology, Neurological Surgery, Brain Tumor Research Center, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Thiele+CJ%22">Thiele CJ</searchLink>; Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Stegmaier+K%22">Stegmaier K</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
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