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Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.

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Title: Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.
Authors: Chen XQ; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540. Electronic address: xue-qing.chen@bms.com., Ziemba T; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540., Huang C; Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Princeton, New Jersey 08540., Chang M; Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb, Pennington, New Jersey 08534., Xu C; Bioanalytical Sciences, Bristol-Myers Squibb, Princeton, New Jersey 08540., Qiao JX; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540., Wang TC; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540., Finlay HJ; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540., Salvati ME; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540., Adam LP; Discovery Biology, Bristol-Myers Squibb, Pennington, New Jersey 08540., Gudmundsson O; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540., Hageman MJ; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540.
Source: Journal of pharmaceutical sciences [J Pharm Sci] 2018 May; Vol. 107 (5), pp. 1352-1360. Date of Electronic Publication: 2018 Jan 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.
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  Data: <searchLink fieldCode="AU" term="%22Chen+XQ%22">Chen XQ</searchLink>; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540. Electronic address: xue-qing.chen@bms.com.<br /><searchLink fieldCode="AU" term="%22Ziemba+T%22">Ziemba T</searchLink>; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Princeton, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Chang+M%22">Chang M</searchLink>; Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb, Pennington, New Jersey 08534.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Bioanalytical Sciences, Bristol-Myers Squibb, Princeton, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Qiao+JX%22">Qiao JX</searchLink>; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Wang+TC%22">Wang TC</searchLink>; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Finlay+HJ%22">Finlay HJ</searchLink>; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Salvati+ME%22">Salvati ME</searchLink>; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Adam+LP%22">Adam LP</searchLink>; Discovery Biology, Bristol-Myers Squibb, Pennington, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Gudmundsson+O%22">Gudmundsson O</searchLink>; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540.<br /><searchLink fieldCode="AU" term="%22Hageman+MJ%22">Hageman MJ</searchLink>; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540.
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  Data: <searchLink fieldCode="JN" term="%222985195R%22">Journal of pharmaceutical sciences</searchLink> [J Pharm Sci] 2018 May; Vol. 107 (5), pp. 1352-1360. <i>Date of Electronic Publication: </i>2018 Jan 06.
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