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Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.

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Title: Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.
Authors: Seibert TM; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA tseibert@ucsd.edu amdale@ucsd.edu.; Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, USA., Fan CC; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.; Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA., Wang Y; NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway., Zuber V; NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.; MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK., Karunamuni R; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.; Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, USA., Parsons JK; Department of Surgery, University of California, San Diego, La Jolla, CA, USA., Eeles RA; Institute of Cancer Research, London, SM2 5NG, UK.; Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK., Kote-Jarai Z; Institute of Cancer Research, London, SM2 5NG, UK., Al Olama AA; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.; Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, R3, Box 83, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Garcia SB; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK., Muir K; Institute of Population Health, University of Manchester, Manchester, UK.; Warwick Medical School, University of Warwick, Coventry, UK., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Wiklund F; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Aly M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Solna, 171 76 Stockholm, Sweden.; Department of Urology, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden., Schleutker J; Department of Medical Biochemistry and Genetics, Institute of Biomedicine, Kiinamyllynkatu 10, FI-20014 University of Turku, Finland.; Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, Turku, Finland.; BioMediTech, 30014 University of Tampere, Tampere, Finland., Sipeky C; Department of Medical Biochemistry and Genetics, Institute of Biomedicine, Kiinamyllynkatu 10, FI-20014 University of Turku, Finland.; Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, Turku, Finland., Tammela TL; Department of Urology, Tampere University Hospital and Medical School, University of Tampere, Finland., Nordestgaard BG; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Nielsen SF; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Weischer M; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Bisbjerg R; Department of Urology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Røder MA; Copenhagen Prostate Cancer Centre, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Iversen P; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Copenhagen Prostate Cancer Centre, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Key TJ; Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford OX3 7LF, UK., Travis RC; Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford OX3 7LF, UK., Neal DE; Nuffield Department of Surgical Sciences, Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, UK.; University of Cambridge, Department of Oncology, Box 279, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Donovan JL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2PS, UK., Hamdy FC; Nuffield Department of Surgical Sciences, Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, UK., Pharoah P; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Pashayan N; University College London, Department of Applied Health Research, London WC1E 7HB, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Khaw KT; Clinical Gerontology Unit, University of Cambridge, Cambridge UK., Maier C; Institute of Human Genetics, University Hospital of Ulm, Ulm, Germany., Vogel W; Institute of Human Genetics, University Hospital of Ulm, Ulm, Germany., Luedeke M; Institute of Human Genetics, University Hospital of Ulm, Ulm, Germany., Herkommer K; Department of Urology, Klinikum rechts der Isar der Technischen Universitaet Muenchen, Munich, Germany., Kibel AS; Division of Urologic Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, 75 Francis Street, Boston, MA 02115, USA., Cybulski C; International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Wokolorczyk D; International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Kluzniak W; International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Cannon-Albright L; Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Cuk K; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Saum KU; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Park JY; Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA., Sellers TA; Office of the Center Director, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA., Slavov C; Department of Urology and Alexandrovska University Hospital, Medical University, Sofia, Bulgaria., Kaneva R; Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University, Sofia, 2 Zdrave Str, 1431 Sofia, Bulgaria., Mitev V; Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University, Sofia, 2 Zdrave Str, 1431 Sofia, Bulgaria., Batra J; Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, Australia., Clements JA; Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, Australia., Spurdle A; Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.; Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, Australia.; Australian Prostate Cancer BioResource, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, Australia., Teixeira MR; Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal., Paulo P; Department of Genetics, Portuguese Oncology Institute, Porto, Portugal., Maia S; Department of Genetics, Portuguese Oncology Institute, Porto, Portugal., Pandha H; University of Surrey, Guildford, Surrey, GU2 7XH., Michael A; University of Surrey, Guildford, Surrey, GU2 7XH., Kierzek A; University of Surrey, Guildford, Surrey, GU2 7XH., Karow DS; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.; Department of Radiology, University of California, San Diego, La Jolla, CA, USA., Mills IG; NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, UK.; Nuffield Department of Surgical Sciences, Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, UK., Andreassen OA; NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway., Dale AM; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA tseibert@ucsd.edu amdale@ucsd.edu.; Department of Radiology, University of California, San Diego, La Jolla, CA, USA.; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Corporate Authors: PRACTICAL Consortium*
Source: BMJ (Clinical research ed.) [BMJ] 2018 Jan 10; Vol. 360, pp. j5757. Date of Electronic Publication: 2018 Jan 10.
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: British Medical Association Country of Publication: England NLM ID: 8900488 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-1833 (Electronic) Linking ISSN: 09598138 NLM ISO Abbreviation: BMJ Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.
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  Data: <searchLink fieldCode="AU" term="%22Seibert+TM%22">Seibert TM</searchLink>; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA tseibert@ucsd.edu amdale@ucsd.edu.; Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fan+CC%22">Fan CC</searchLink>; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.; Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Zuber+V%22">Zuber V</searchLink>; NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.; MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK.<br /><searchLink fieldCode="AU" term="%22Karunamuni+R%22">Karunamuni R</searchLink>; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.; Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Parsons+JK%22">Parsons JK</searchLink>; Department of Surgery, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Eeles+RA%22">Eeles RA</searchLink>; Institute of Cancer Research, London, SM2 5NG, UK.; Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.<br /><searchLink fieldCode="AU" term="%22Easton+DF%22">Easton DF</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Kote-Jarai+Z%22">Kote-Jarai Z</searchLink>; Institute of Cancer Research, London, SM2 5NG, UK.<br /><searchLink fieldCode="AU" term="%22Al+Olama+AA%22">Al Olama AA</searchLink>; 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            NameFull: Michael A
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          Name:
            NameFull: Karow DS
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    IsPartOfRelationships:
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          Dates:
            – D: 10
              M: 01
              Text: 2018 Jan 10
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-electronic
              Value: 1756-1833
          Numbering:
            – Type: volume
              Value: 360
          Titles:
            – TitleFull: BMJ (Clinical research ed.)
              Type: main
ResultId 1