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Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.

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Title: Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.
Authors: Lan Y; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA. yan.lan@emdserono.com kinming.lo@emdserono.com., Zhang D; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Xu C; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Hance KW; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Marelli B; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Qi J; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Yu H; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Qin G; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Sircar A; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Hernández VM; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Jenkins MH; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Fontana RE; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Deshpande A; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Locke G; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Sabzevari H; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Radvanyi L; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA., Lo KM; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA. yan.lan@emdserono.com kinming.lo@emdserono.com.
Source: Science translational medicine [Sci Transl Med] 2018 Jan 17; Vol. 10 (424).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.
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  Data: <searchLink fieldCode="AU" term="%22Lan+Y%22">Lan Y</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA. yan.lan@emdserono.com kinming.lo@emdserono.com.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Hance+KW%22">Hance KW</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Marelli+B%22">Marelli B</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Qin+G%22">Qin G</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Sircar+A%22">Sircar A</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Hernández+VM%22">Hernández VM</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+MH%22">Jenkins MH</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Fontana+RE%22">Fontana RE</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Deshpande+A%22">Deshpande A</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Locke+G%22">Locke G</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Sabzevari+H%22">Sabzevari H</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Radvanyi+L%22">Radvanyi L</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.<br /><searchLink fieldCode="AU" term="%22Lo+KM%22">Lo KM</searchLink>; EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA. yan.lan@emdserono.com kinming.lo@emdserono.com.
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