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Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway.

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Title: Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway.
Authors: Break MKB; Centre for Natural and Medicinal Product Research, School of Pharmacy, University of Nottingham Malaysia Campus, 43500 Semenyih, Malaysia., Hossan MS; School of Pharmacy, Centre for Biomolecular Science, University of Nottingham, University Park, Nottingham, UK., Khoo Y; Centre for Natural and Medicinal Product Research, School of Pharmacy, University of Nottingham Malaysia Campus, 43500 Semenyih, Malaysia., Qazzaz ME; School of Pharmacy, Centre for Biomolecular Science, University of Nottingham, University Park, Nottingham, UK., Al-Hayali MZK; School of Pharmacy, Centre for Biomolecular Science, University of Nottingham, University Park, Nottingham, UK., Chow SC; School of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway 46150, Selangor Darul Ehsan, Malaysia., Wiart C; Centre for Natural and Medicinal Product Research, School of Pharmacy, University of Nottingham Malaysia Campus, 43500 Semenyih, Malaysia., Bradshaw TD; School of Pharmacy, Centre for Biomolecular Science, University of Nottingham, University Park, Nottingham, UK., Collins H; School of Pharmacy, Centre for Biomolecular Science, University of Nottingham, University Park, Nottingham, UK., Khoo TJ; Centre for Natural and Medicinal Product Research, School of Pharmacy, University of Nottingham Malaysia Campus, 43500 Semenyih, Malaysia. Electronic address: TengJin.Khoo@nottingham.edu.my.
Source: Fitoterapia [Fitoterapia] 2018 Mar; Vol. 125, pp. 161-173. Date of Electronic Publication: 2018 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-6971
DOI:10.1016/j.fitote.2018.01.006