Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation.
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| Title: | Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation. |
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| Authors: | Narayanan B; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA., Lade JM; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA., Heck CJS; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA., Dietz KD; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA., Wade H; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA., Bumpus NN; Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA. |
| Source: | ChemMedChem [ChemMedChem] 2018 Apr 06; Vol. 13 (7), pp. 736-747. Date of Electronic Publication: 2018 Mar 02. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 29430850 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Narayanan+B%22">Narayanan B</searchLink>; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lade+JM%22">Lade JM</searchLink>; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Heck+CJS%22">Heck CJS</searchLink>; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dietz+KD%22">Dietz KD</searchLink>; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wade+H%22">Wade H</searchLink>; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bumpus+NN%22">Bumpus NN</searchLink>; Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101259013%22">ChemMedChem</searchLink> [ChemMedChem] 2018 Apr 06; Vol. 13 (7), pp. 736-747. <i>Date of Electronic Publication: </i>2018 Mar 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-VCH%22">Wiley-VCH </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101259013 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1860-7187 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218607179%22">18607179 </searchLink><i>NLM ISO Abbreviation: </i>ChemMedChem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=29430850 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/cmdc.201700730 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 736 Titles: – TitleFull: Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Narayanan B – PersonEntity: Name: NameFull: Lade JM – PersonEntity: Name: NameFull: Heck CJS – PersonEntity: Name: NameFull: Dietz KD – PersonEntity: Name: NameFull: Wade H – PersonEntity: Name: NameFull: Bumpus NN IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 04 Text: 2018 Apr 06 Type: published Y: 2018 Identifiers: – Type: issn-electronic Value: 1860-7187 Numbering: – Type: volume Value: 13 – Type: issue Value: 7 Titles: – TitleFull: ChemMedChem Type: main |
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