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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).

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Bibliographic Details
Title: A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
Authors: Miller ML; ImmunoGen, Inc., Waltham, Massachusetts., Shizuka M; ImmunoGen, Inc., Waltham, Massachusetts., Wilhelm A; ImmunoGen, Inc., Waltham, Massachusetts., Salomon P; ImmunoGen, Inc., Waltham, Massachusetts., Reid EE; ImmunoGen, Inc., Waltham, Massachusetts., Lanieri L; ImmunoGen, Inc., Waltham, Massachusetts., Sikka S; ImmunoGen, Inc., Waltham, Massachusetts., Maloney EK; ImmunoGen, Inc., Waltham, Massachusetts., Harvey L; ImmunoGen, Inc., Waltham, Massachusetts., Qiu Q; ImmunoGen, Inc., Waltham, Massachusetts., Archer KE; ImmunoGen, Inc., Waltham, Massachusetts., Bai C; ImmunoGen, Inc., Waltham, Massachusetts., Vitharana D; ImmunoGen, Inc., Waltham, Massachusetts., Harris L; ImmunoGen, Inc., Waltham, Massachusetts., Singh R; ImmunoGen, Inc., Waltham, Massachusetts., Ponte JF; ImmunoGen, Inc., Waltham, Massachusetts., Yoder NC; ImmunoGen, Inc., Waltham, Massachusetts., Kovtun Y; ImmunoGen, Inc., Waltham, Massachusetts., Lai KC; ImmunoGen, Inc., Waltham, Massachusetts., Ab O; ImmunoGen, Inc., Waltham, Massachusetts., Pinkas J; ImmunoGen, Inc., Waltham, Massachusetts., Keating TA; ImmunoGen, Inc., Waltham, Massachusetts., Chari RVJ; ImmunoGen, Inc., Waltham, Massachusetts. ravi.chari@immunogen.com.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2018 Mar; Vol. 17 (3), pp. 650-660. Date of Electronic Publication: 2018 Feb 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-8514
DOI:10.1158/1535-7163.MCT-17-0940