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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).

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Title: A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
Authors: Miller ML; ImmunoGen, Inc., Waltham, Massachusetts., Shizuka M; ImmunoGen, Inc., Waltham, Massachusetts., Wilhelm A; ImmunoGen, Inc., Waltham, Massachusetts., Salomon P; ImmunoGen, Inc., Waltham, Massachusetts., Reid EE; ImmunoGen, Inc., Waltham, Massachusetts., Lanieri L; ImmunoGen, Inc., Waltham, Massachusetts., Sikka S; ImmunoGen, Inc., Waltham, Massachusetts., Maloney EK; ImmunoGen, Inc., Waltham, Massachusetts., Harvey L; ImmunoGen, Inc., Waltham, Massachusetts., Qiu Q; ImmunoGen, Inc., Waltham, Massachusetts., Archer KE; ImmunoGen, Inc., Waltham, Massachusetts., Bai C; ImmunoGen, Inc., Waltham, Massachusetts., Vitharana D; ImmunoGen, Inc., Waltham, Massachusetts., Harris L; ImmunoGen, Inc., Waltham, Massachusetts., Singh R; ImmunoGen, Inc., Waltham, Massachusetts., Ponte JF; ImmunoGen, Inc., Waltham, Massachusetts., Yoder NC; ImmunoGen, Inc., Waltham, Massachusetts., Kovtun Y; ImmunoGen, Inc., Waltham, Massachusetts., Lai KC; ImmunoGen, Inc., Waltham, Massachusetts., Ab O; ImmunoGen, Inc., Waltham, Massachusetts., Pinkas J; ImmunoGen, Inc., Waltham, Massachusetts., Keating TA; ImmunoGen, Inc., Waltham, Massachusetts., Chari RVJ; ImmunoGen, Inc., Waltham, Massachusetts. ravi.chari@immunogen.com.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2018 Mar; Vol. 17 (3), pp. 650-660. Date of Electronic Publication: 2018 Feb 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
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  Data: <searchLink fieldCode="AU" term="%22Miller+ML%22">Miller ML</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Shizuka+M%22">Shizuka M</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wilhelm+A%22">Wilhelm A</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Salomon+P%22">Salomon P</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Reid+EE%22">Reid EE</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lanieri+L%22">Lanieri L</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Sikka+S%22">Sikka S</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Maloney+EK%22">Maloney EK</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Harvey+L%22">Harvey L</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Qiu+Q%22">Qiu Q</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Archer+KE%22">Archer KE</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bai+C%22">Bai C</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Vitharana+D%22">Vitharana D</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Harris+L%22">Harris L</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Singh+R%22">Singh R</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ponte+JF%22">Ponte JF</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Yoder+NC%22">Yoder NC</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kovtun+Y%22">Kovtun Y</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lai+KC%22">Lai KC</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ab+O%22">Ab O</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Pinkas+J%22">Pinkas J</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Keating+TA%22">Keating TA</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chari+RVJ%22">Chari RVJ</searchLink>; ImmunoGen, Inc., Waltham, Massachusetts. ravi.chari@immunogen.com.
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  Data: <searchLink fieldCode="JN" term="%22101132535%22">Molecular cancer therapeutics</searchLink> [Mol Cancer Ther] 2018 Mar; Vol. 17 (3), pp. 650-660. <i>Date of Electronic Publication: </i>2018 Feb 13.
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