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Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

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Title: Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Authors: Douse CH; Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0QH, UK. cdouse@mrc-lmb.cam.ac.uk., Bloor S; Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Liu Y; Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0QH, UK., Shamin M; Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0QH, UK., Tchasovnikarova IA; Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA, 02114, USA., Timms RT; Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Lehner PJ; Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Modis Y; Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0QH, UK. ymodis@mrc-lmb.cam.ac.uk.
Source: Nature communications [Nat Commun] 2018 Feb 13; Vol. 9 (1), pp. 651. Date of Electronic Publication: 2018 Feb 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Douse+CH%22">Douse CH</searchLink>; Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0QH, UK. cdouse@mrc-lmb.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Bloor+S%22">Bloor S</searchLink>; Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0QH, UK.<br /><searchLink fieldCode="AU" term="%22Shamin+M%22">Shamin M</searchLink>; Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0QH, UK.<br /><searchLink fieldCode="AU" term="%22Tchasovnikarova+IA%22">Tchasovnikarova IA</searchLink>; Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Timms+RT%22">Timms RT</searchLink>; Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lehner+PJ%22">Lehner PJ</searchLink>; Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Modis+Y%22">Modis Y</searchLink>; Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0QH, UK. ymodis@mrc-lmb.cam.ac.uk.
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