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Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.

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Title: Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
Authors: Stepan AF; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Tran TP; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Helal CJ; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Brown MS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Chang C; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., O'Connor RE; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., De Vivo M; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Doran SD; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Fisher EL; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Jenkinson S; Pfizer Worldwide Research and Development, 10770 Science Center Drive, La Jolla, California 92121, United States., Karanian D; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Kormos BL; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Sharma R; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Walker GS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Wright AS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Yang EX; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Brodney MA; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Wager TT; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Verhoest PR; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Obach RS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jan 04; Vol. 9 (2), pp. 68-72. Date of Electronic Publication: 2018 Jan 04 (Print Publication: 2018).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
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  Data: <searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Tran+TP%22">Tran TP</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Helal+CJ%22">Helal CJ</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Brown+MS%22">Brown MS</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Chang+C%22">Chang C</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22O'Connor+RE%22">O'Connor RE</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22De+Vivo+M%22">De Vivo M</searchLink>; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Doran+SD%22">Doran SD</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Fisher+EL%22">Fisher EL</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Jenkinson+S%22">Jenkinson S</searchLink>; Pfizer Worldwide Research and Development, 10770 Science Center Drive, La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Karanian+D%22">Karanian D</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Kormos+BL%22">Kormos BL</searchLink>; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Sharma+R%22">Sharma R</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Walker+GS%22">Walker GS</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Wright+AS%22">Wright AS</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Yang+EX%22">Yang EX</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Brodney+MA%22">Brodney MA</searchLink>; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Wager+TT%22">Wager TT</searchLink>; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Verhoest+PR%22">Verhoest PR</searchLink>; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Obach+RS%22">Obach RS</searchLink>; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
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