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Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.

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Bibliographic Details
Title: Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
Authors: Stepan AF; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Tran TP; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Helal CJ; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Brown MS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Chang C; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., O'Connor RE; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., De Vivo M; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Doran SD; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Fisher EL; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Jenkinson S; Pfizer Worldwide Research and Development, 10770 Science Center Drive, La Jolla, California 92121, United States., Karanian D; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Kormos BL; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Sharma R; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Walker GS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Wright AS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Yang EX; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Brodney MA; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Wager TT; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Verhoest PR; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States., Obach RS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jan 04; Vol. 9 (2), pp. 68-72. Date of Electronic Publication: 2018 Jan 04 (Print Publication: 2018).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.7b00343