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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

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Title: BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
Authors: McArthur K; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. kate.mcarthur@monash.edu benjamin.kile@monash.edu.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Whitehead LW; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Heddleston JM; Advanced Imaging Center, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA., Li L; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Padman BS; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Oorschot V; Monash Ramaciotti Centre for Cryo Electron Microscopy, Monash University, Melbourne, Victoria, Australia., Geoghegan ND; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Chappaz S; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Davidson S; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., San Chin H; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Lane RM; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Dramicanin M; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Saunders TL; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Sugiana C; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Lessene R; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Osellame LD; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Chew TL; Advanced Imaging Center, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA., Dewson G; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Lazarou M; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Ramm G; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.; Monash Ramaciotti Centre for Cryo Electron Microscopy, Monash University, Melbourne, Victoria, Australia., Lessene G; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia., Ryan MT; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Rogers KL; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., van Delft MF; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Kile BT; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. kate.mcarthur@monash.edu benjamin.kile@monash.edu.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Source: Science (New York, N.Y.) [Science] 2018 Feb 23; Vol. 359 (6378).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
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  Data: <searchLink fieldCode="AU" term="%22McArthur+K%22">McArthur K</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. kate.mcarthur@monash.edu benjamin.kile@monash.edu.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Whitehead+LW%22">Whitehead LW</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Heddleston+JM%22">Heddleston JM</searchLink>; Advanced Imaging Center, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Padman+BS%22">Padman BS</searchLink>; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Oorschot+V%22">Oorschot V</searchLink>; Monash Ramaciotti Centre for Cryo Electron Microscopy, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Geoghegan+ND%22">Geoghegan ND</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chappaz+S%22">Chappaz S</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Davidson+S%22">Davidson S</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22San+Chin+H%22">San Chin H</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lane+RM%22">Lane RM</searchLink>; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Dramicanin+M%22">Dramicanin M</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Saunders+TL%22">Saunders TL</searchLink>; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sugiana+C%22">Sugiana C</searchLink>; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lessene+R%22">Lessene R</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Osellame+LD%22">Osellame LD</searchLink>; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chew+TL%22">Chew TL</searchLink>; Advanced Imaging Center, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA.<br /><searchLink fieldCode="AU" term="%22Dewson+G%22">Dewson G</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lazarou+M%22">Lazarou M</searchLink>; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ramm+G%22">Ramm G</searchLink>; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.; Monash Ramaciotti Centre for Cryo Electron Microscopy, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lessene+G%22">Lessene G</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ryan+MT%22">Ryan MT</searchLink>; Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rogers+KL%22">Rogers KL</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22van+Delft+MF%22">van Delft MF</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kile+BT%22">Kile BT</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. kate.mcarthur@monash.edu benjamin.kile@monash.edu.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
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