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Unexplored therapeutic opportunities in the human genome.

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Title: Unexplored therapeutic opportunities in the human genome.
Authors: Oprea TI; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.; UNM Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bologa CG; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Campbell A; IQVIA, Plymouth Meeting, PA, USA., Gan GN; UNM Comprehensive Cancer Center, Albuquerque, NM, USA., Gaulton A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK., Gomez SM; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Guha R; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA., Hersey A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK., Holmes J; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Jadhav A; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA., Jensen LJ; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Johnson GL; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Karlson A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.; SciBite Limited, BioData Innovation Centre, Wellcome Genome Campus, Hinxton, Cambridge, UK., Leach AR; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK., Ma'ayan A; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Malovannaya A; Baylor College of Medicine, Houston, TX, USA., Mani S; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Mathias SL; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., McManus MT; University of California, San Francisco, CA, USA., Meehan TF; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK., von Mering C; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Muthas D; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Nguyen DT; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA., Overington JP; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.; Medicines Discovery Catapult, Alderley Edge, UK., Papadatos G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.; GlaxoSmithKline, Stevenage, UK., Qin J; Baylor College of Medicine, Houston, TX, USA., Reich C; IQVIA, Cambridge, MA, USA., Roth BL; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Schürer SC; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA., Simeonov A; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA., Sklar LA; UNM Comprehensive Cancer Center, Albuquerque, NM, USA.; Center for Molecular Discovery, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM, USA.; Department of Pathology, University of New Mexico, Albuquerque, NM, USA., Southall N; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA., Tomita S; Yale School of Medicine, Yale University, New Haven, CT, USA., Tudose I; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.; Google Germany GmbH, München, Germany., Ursu O; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Vidovic D; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA., Waller A; Center for Molecular Discovery, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM, USA., Westergaard D; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Yang JJ; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA., Zahoránszky-Köhalmi G; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.; NIH-NCATS, Rockville, MD, USA.
Source: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2018 May; Vol. 17 (5), pp. 317-332. Date of Electronic Publication: 2018 Mar 23.
Publication Type: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: PubMed not MEDLINE
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