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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

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Title: Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
Authors: McAllister LA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Butler CR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Mente S; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., O'Neil SV; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Fonseca KR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Piro JR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Cianfrogna JA; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Foley TL; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Gilbert AM; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Harris AR; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Helal CJ; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Johnson DS; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Montgomery JI; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Nason DM; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Noell S; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Pandit J; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Rogers BN; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Samad TA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Shaffer CL; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., da Silva RG; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Uccello DP; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Webb D; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Brodney MA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.
Source: Journal of medicinal chemistry [J Med Chem] 2018 Apr 12; Vol. 61 (7), pp. 3008-3026. Date of Electronic Publication: 2018 Mar 15.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22McAllister+LA%22">McAllister LA</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22Butler+CR%22">Butler CR</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22Mente+S%22">Mente S</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22O'Neil+SV%22">O'Neil SV</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Fonseca+KR%22">Fonseca KR</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22Piro+JR%22">Piro JR</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22Cianfrogna+JA%22">Cianfrogna JA</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Foley+TL%22">Foley TL</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Gilbert+AM%22">Gilbert AM</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Harris+AR%22">Harris AR</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Helal+CJ%22">Helal CJ</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Johnson+DS%22">Johnson DS</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22Montgomery+JI%22">Montgomery JI</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Nason+DM%22">Nason DM</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Noell+S%22">Noell S</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Pandit+J%22">Pandit J</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Rogers+BN%22">Rogers BN</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22Samad+TA%22">Samad TA</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22Shaffer+CL%22">Shaffer CL</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22da+Silva+RG%22">da Silva RG</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Uccello+DP%22">Uccello DP</searchLink>; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Webb+D%22">Webb D</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.<br /><searchLink fieldCode="AU" term="%22Brodney+MA%22">Brodney MA</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2018 Apr 12; Vol. 61 (7), pp. 3008-3026. <i>Date of Electronic Publication: </i>2018 Mar 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=29498843
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        Value: 10.1021/acs.jmedchem.8b00070
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      – Code: eng
        Text: English
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        StartPage: 3008
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      – TitleFull: Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
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              Text: 2018 Apr 12
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