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SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors.

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Title: SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors.
Authors: Dardaei L; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Wang HQ; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Singh M; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Fordjour P; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Shaw KX; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Yoda S; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Kerr G; Novartis Institutes for BioMedical Research, Basal, Switzerland., Yu K; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Liang J; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Cao Y; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Chen Y; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Lawrence MS; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA., Langenbucher A; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Gainor JF; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Friboulet L; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Dagogo-Jack I; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Myers DT; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Labrot E; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Ruddy D; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Parks M; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Lee D; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., DiCecca RH; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Moody S; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Hao H; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Mohseni M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., LaMarche M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Williams J; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Hoffmaster K; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Caponigro G; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Shaw AT; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Hata AN; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Benes CH; Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Li F; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Engelman JA; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Source: Nature medicine [Nat Med] 2018 May; Vol. 24 (4), pp. 512-517. Date of Electronic Publication: 2018 Mar 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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