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Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

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Title: Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
Authors: Infante P; Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy., Faedda R; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Bernardi F; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Bufalieri F; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Lospinoso Severini L; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Alfonsi R; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Mazzà D; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Siler M; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Coni S; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Po A; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Petroni M; Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy., Ferretti E; Department of Experimental Medicine, University La Sapienza, 00161, Rome, Italy., Mori M; Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy., De Smaele E; Department of Experimental Medicine, University La Sapienza, 00161, Rome, Italy., Canettieri G; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.; Istituto Pasteur-Fondazione Cenci Bolognetti, University La Sapienza, 00161, Rome, Italy., Capalbo C; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Maroder M; Department of Medico-Surgical Sciences and Biotechnologies, University La Sapienza, 00161, Rome, Italy., Screpanti I; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Kool M; Hopp Children's Cancer Center at the NCT (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany., Pfister SM; Hopp Children's Cancer Center at the NCT (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Guardavaccaro D; Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584CT, Utrecht, The Netherlands., Gulino A; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Di Marcotullio L; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy. lucia.dimarcotullio@uniroma1.it.; Istituto Pasteur-Fondazione Cenci Bolognetti, University La Sapienza, 00161, Rome, Italy. lucia.dimarcotullio@uniroma1.it.
Source: Nature communications [Nat Commun] 2018 Mar 07; Vol. 9 (1), pp. 976. Date of Electronic Publication: 2018 Mar 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
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  Data: <searchLink fieldCode="AU" term="%22Infante+P%22">Infante P</searchLink>; Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Faedda+R%22">Faedda R</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+F%22">Bernardi F</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bufalieri+F%22">Bufalieri F</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lospinoso+Severini+L%22">Lospinoso Severini L</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Alfonsi+R%22">Alfonsi R</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzà+D%22">Mazzà D</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Siler+M%22">Siler M</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Coni+S%22">Coni S</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Po+A%22">Po A</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Petroni+M%22">Petroni M</searchLink>; Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ferretti+E%22">Ferretti E</searchLink>; Department of Experimental Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mori+M%22">Mori M</searchLink>; Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Smaele+E%22">De Smaele E</searchLink>; Department of Experimental Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Canettieri+G%22">Canettieri G</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.; Istituto Pasteur-Fondazione Cenci Bolognetti, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Capalbo+C%22">Capalbo C</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Maroder+M%22">Maroder M</searchLink>; Department of Medico-Surgical Sciences and Biotechnologies, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Screpanti+I%22">Screpanti I</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Kool+M%22">Kool M</searchLink>; Hopp Children's Cancer Center at the NCT (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center at the NCT (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Guardavaccaro+D%22">Guardavaccaro D</searchLink>; Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gulino+A%22">Gulino A</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Marcotullio+L%22">Di Marcotullio L</searchLink>; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy. lucia.dimarcotullio@uniroma1.it.; Istituto Pasteur-Fondazione Cenci Bolognetti, University La Sapienza, 00161, Rome, Italy. lucia.dimarcotullio@uniroma1.it.
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