Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

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Title: Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.
Authors: Matic S; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany., Jiang M; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany., Nicholls TJ; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden., Uhler JP; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden., Dirksen-Schwanenland C; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany., Polosa PL; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Bari, 70125, Italy., Simard ML; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany., Li X; Proteomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany., Atanassov I; Proteomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany., Rackham O; Harry Perkins Institute of Medical Research Centre for Medical Research and School of Molecular Sciences, The University of Western Australia, Nedlands, WA 6009, Australia., Filipovska A; Harry Perkins Institute of Medical Research Centre for Medical Research and School of Molecular Sciences, The University of Western Australia, Nedlands, WA 6009, Australia., Stewart JB; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany., Falkenberg M; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden., Larsson NG; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany. nils-goran.larsson@ki.se.; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden. nils-goran.larsson@ki.se., Milenkovic D; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany. dmilenkovic@age.mpg.de.
Source: Nature communications [Nat Commun] 2018 Mar 23; Vol. 9 (1), pp. 1202. Date of Electronic Publication: 2018 Mar 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.
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  Data: <searchLink fieldCode="AU" term="%22Matic+S%22">Matic S</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Jiang+M%22">Jiang M</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Nicholls+TJ%22">Nicholls TJ</searchLink>; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Uhler+JP%22">Uhler JP</searchLink>; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Dirksen-Schwanenland+C%22">Dirksen-Schwanenland C</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Polosa+PL%22">Polosa PL</searchLink>; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Bari, 70125, Italy.<br /><searchLink fieldCode="AU" term="%22Simard+ML%22">Simard ML</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Proteomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Atanassov+I%22">Atanassov I</searchLink>; Proteomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Rackham+O%22">Rackham O</searchLink>; Harry Perkins Institute of Medical Research Centre for Medical Research and School of Molecular Sciences, The University of Western Australia, Nedlands, WA 6009, Australia.<br /><searchLink fieldCode="AU" term="%22Filipovska+A%22">Filipovska A</searchLink>; Harry Perkins Institute of Medical Research Centre for Medical Research and School of Molecular Sciences, The University of Western Australia, Nedlands, WA 6009, Australia.<br /><searchLink fieldCode="AU" term="%22Stewart+JB%22">Stewart JB</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Falkenberg+M%22">Falkenberg M</searchLink>; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Larsson+NG%22">Larsson NG</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany. nils-goran.larsson@ki.se.; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden. nils-goran.larsson@ki.se.<br /><searchLink fieldCode="AU" term="%22Milenkovic+D%22">Milenkovic D</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany. dmilenkovic@age.mpg.de.
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