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Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

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Title: Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Authors: Zyryanova AF; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. az310@cam.ac.uk ajw1000@cam.ac.uk dr360@medschl.cam.ac.uk., Weis F; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK., Faille A; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK., Alard AA; Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Crespillo-Casado A; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Sekine Y; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Harding HP; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Allen F; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Parts L; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Fromont C; Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Fischer PM; Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Warren AJ; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. az310@cam.ac.uk ajw1000@cam.ac.uk dr360@medschl.cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK., Ron D; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. az310@cam.ac.uk ajw1000@cam.ac.uk dr360@medschl.cam.ac.uk.
Source: Science (New York, N.Y.) [Science] 2018 Mar 30; Vol. 359 (6383), pp. 1533-1536.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
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  Data: <searchLink fieldCode="AU" term="%22Zyryanova+AF%22">Zyryanova AF</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. az310@cam.ac.uk ajw1000@cam.ac.uk dr360@medschl.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Weis+F%22">Weis F</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.<br /><searchLink fieldCode="AU" term="%22Faille+A%22">Faille A</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Alard+AA%22">Alard AA</searchLink>; Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Crespillo-Casado+A%22">Crespillo-Casado A</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Sekine+Y%22">Sekine Y</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Harding+HP%22">Harding HP</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Allen+F%22">Allen F</searchLink>; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Parts+L%22">Parts L</searchLink>; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Fromont+C%22">Fromont C</searchLink>; Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Fischer+PM%22">Fischer PM</searchLink>; Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Warren+AJ%22">Warren AJ</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. az310@cam.ac.uk ajw1000@cam.ac.uk dr360@medschl.cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.<br /><searchLink fieldCode="AU" term="%22Ron+D%22">Ron D</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. az310@cam.ac.uk ajw1000@cam.ac.uk dr360@medschl.cam.ac.uk.
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