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Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.

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Title: Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.
Authors: Obach RS; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Walker GS; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Sharma R; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Jenkinson S; Pfizer Worldwide Research and Development , 10770 Science Center Drive , La Jolla , California 92121 , United States., Tran TP; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Stepan AF; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.
Source: Journal of medicinal chemistry [J Med Chem] 2018 Apr 26; Vol. 61 (8), pp. 3626-3640. Date of Electronic Publication: 2018 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Obach+RS%22">Obach RS</searchLink>; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Walker+GS%22">Walker GS</searchLink>; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Sharma+R%22">Sharma R</searchLink>; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Jenkinson+S%22">Jenkinson S</searchLink>; Pfizer Worldwide Research and Development , 10770 Science Center Drive , La Jolla , California 92121 , United States.<br /><searchLink fieldCode="AU" term="%22Tran+TP%22">Tran TP</searchLink>; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.<br /><searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2018 Apr 26; Vol. 61 (8), pp. 3626-3640. <i>Date of Electronic Publication: </i>2018 Apr 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1021/acs.jmedchem.8b00116
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      – Code: eng
        Text: English
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        StartPage: 3626
    Titles:
      – TitleFull: Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.
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            NameFull: Obach RS
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            NameFull: Walker GS
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            NameFull: Sharma R
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            NameFull: Tran TP
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            – D: 26
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              Text: 2018 Apr 26
              Type: published
              Y: 2018
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              Value: 61
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              Value: 8
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            – TitleFull: Journal of medicinal chemistry
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