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Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.

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Title: Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.
Authors: Rossi Sebastiano M; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden., Doak BC; Department of Medicinal Chemistry, MIPS , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia., Backlund M; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a Node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Department of Pharmacy, BMC , Uppsala University , Box 580, SE-751 23 Uppsala , Sweden., Poongavanam V; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden., Over B; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit , AstraZeneca R&D Gothenburg , SE-431 83 Mölndal , Sweden., Ermondi G; Department of Molecular Biotechnology and Health Sciences , University of Torino , Quarello 15 , 10135 Torino , Italy., Caron G; Department of Molecular Biotechnology and Health Sciences , University of Torino , Quarello 15 , 10135 Torino , Italy., Matsson P; Department of Pharmacy, BMC , Uppsala University , Box 580, SE-751 23 Uppsala , Sweden., Kihlberg J; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden.
Source: Journal of medicinal chemistry [J Med Chem] 2018 May 10; Vol. 61 (9), pp. 4189-4202. Date of Electronic Publication: 2018 Apr 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.
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  Data: <searchLink fieldCode="AU" term="%22Rossi+Sebastiano+M%22">Rossi Sebastiano M</searchLink>; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden.<br /><searchLink fieldCode="AU" term="%22Doak+BC%22">Doak BC</searchLink>; Department of Medicinal Chemistry, MIPS , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.<br /><searchLink fieldCode="AU" term="%22Backlund+M%22">Backlund M</searchLink>; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a Node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Department of Pharmacy, BMC , Uppsala University , Box 580, SE-751 23 Uppsala , Sweden.<br /><searchLink fieldCode="AU" term="%22Poongavanam+V%22">Poongavanam V</searchLink>; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden.<br /><searchLink fieldCode="AU" term="%22Over+B%22">Over B</searchLink>; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit , AstraZeneca R&D Gothenburg , SE-431 83 Mölndal , Sweden.<br /><searchLink fieldCode="AU" term="%22Ermondi+G%22">Ermondi G</searchLink>; Department of Molecular Biotechnology and Health Sciences , University of Torino , Quarello 15 , 10135 Torino , Italy.<br /><searchLink fieldCode="AU" term="%22Caron+G%22">Caron G</searchLink>; Department of Molecular Biotechnology and Health Sciences , University of Torino , Quarello 15 , 10135 Torino , Italy.<br /><searchLink fieldCode="AU" term="%22Matsson+P%22">Matsson P</searchLink>; Department of Pharmacy, BMC , Uppsala University , Box 580, SE-751 23 Uppsala , Sweden.<br /><searchLink fieldCode="AU" term="%22Kihlberg+J%22">Kihlberg J</searchLink>; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2018 May 10; Vol. 61 (9), pp. 4189-4202. <i>Date of Electronic Publication: </i>2018 Apr 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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