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Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

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Title: Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.
Authors: Koundinya M; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Sudhalter J; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Courjaud A; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Lionne B; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Touyer G; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Bonnet L; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Menguy I; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Schreiber I; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Perrault C; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Vougier S; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Benhamou B; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Zhang B; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., He T; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Gao Q; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Gee P; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Simard D; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Castaldi MP; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Tomlinson R; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Reiling S; LGCR-SDI, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Barrague M; LGCR, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Newcombe R; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Cao H; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Wang Y; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Sun F; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Murtie J; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Munson M; LGCR, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Yang E; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Harper D; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Bouaboula M; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Pollard J; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Grepin C; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Garcia-Echeverria C; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Cheng H; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Adrian F; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Winter C; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Licht S; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. Electronic address: sslicht@gmail.com., Cornella-Taracido I; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Arrebola R; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Morris A; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. Electronic address: aaronjmorris@gmail.com.
Source: Cell chemical biology [Cell Chem Biol] 2018 Jun 21; Vol. 25 (6), pp. 705-717.e11. Date of Electronic Publication: 2018 Apr 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
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  Data: Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.
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Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Cao+H%22">Cao H</searchLink>; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Sun+F%22">Sun F</searchLink>; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Murtie+J%22">Murtie J</searchLink>; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Munson+M%22">Munson M</searchLink>; LGCR, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Yang+E%22">Yang E</searchLink>; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Harper+D%22">Harper D</searchLink>; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Bouaboula+M%22">Bouaboula M</searchLink>; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Pollard+J%22">Pollard J</searchLink>; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Grepin+C%22">Grepin C</searchLink>; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France.<br /><searchLink fieldCode="AU" term="%22Garcia-Echeverria+C%22">Garcia-Echeverria C</searchLink>; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+H%22">Cheng H</searchLink>; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Adrian+F%22">Adrian F</searchLink>; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Winter+C%22">Winter C</searchLink>; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Licht+S%22">Licht S</searchLink>; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. 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