Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.
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| Title: | Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers. |
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| Authors: | Koundinya M; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Sudhalter J; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Courjaud A; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Lionne B; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Touyer G; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Bonnet L; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Menguy I; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Schreiber I; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Perrault C; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Vougier S; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Benhamou B; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Zhang B; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., He T; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Gao Q; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Gee P; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Simard D; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Castaldi MP; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Tomlinson R; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Reiling S; LGCR-SDI, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Barrague M; LGCR, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Newcombe R; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Cao H; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Wang Y; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Sun F; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Murtie J; In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Munson M; LGCR, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Yang E; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Harper D; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Bouaboula M; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Pollard J; TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Grepin C; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Garcia-Echeverria C; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Cheng H; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Adrian F; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Winter C; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Licht S; Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. Electronic address: sslicht@gmail.com., Cornella-Taracido I; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA., Arrebola R; LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France., Morris A; Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. Electronic address: aaronjmorris@gmail.com. |
| Source: | Cell chemical biology [Cell Chem Biol] 2018 Jun 21; Vol. 25 (6), pp. 705-717.e11. Date of Electronic Publication: 2018 Apr 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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