Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

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Title: Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).
Authors: Bergmeijer TO; St Antonius Center for Platelet Function Research, Department of Cardiology, St Antonius Hospital Nieuwegein, the Netherlands., Reny JL; Internal Medicine, Béziers Hospital, France, Geneva Platelet Group, University of Geneva School of Medicine, Department of Internal Medicine, Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva, Switzerland., Pakyz RE; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Gong L; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Lewis JP; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Kim EY; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea., Aradi D; Heart Center Balatonfüred and Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Fernandez-Cadenas I; Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Neurovascular Research Laboratory, Valle d'Hebron Hebron Institute of Research, Barcelona, Spain., Horenstein RB; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Lee MTM; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA., Whaley RM; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Montaner J; Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Barcelona, Spain., Gensini GF; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Cleator JH; Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA., Chang K; Cardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea., Holmvang L; Department of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Hochholzer W; University Heart Center Freiburg, Bad Krozingen, Department of Cardiology and Angiology II, Bad Krozingen, Germany., Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA., Winter S; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany., Altman RB; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA; Departments of Bioengineering and Genetics, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA., Alexopoulos D; Department of Cardiology, Patras University Hospital, Patras, Greece., Kim HS; Department of Pharmacology and Pharmacogenomics Research Center, College of Medicine, Inje University, Busan, South Korea., Déry JP; Quebec Heart and Lung Institute, Québec, Canada., Gawaz M; Department of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany., Bliden K; Inova Center for Thrombosis Research and Drug Development. Inova Heart and Vascular Institute, Falls Church, VA, USA., Valgimigli M; Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland., Marcucci R; Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy., Campo G; Cardiology Unit, Azienda Ospedaliera Universitria di Ferrara, Cona (FE) and Maria Cecilia Hospital, GVM Care and Research, Cotignola, (RA), Italy., Schaeffeler E; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany., Dridi NP; Department of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Wen MS; Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou and School of Medicine, Chang Gung University, Taoyuan City, Taiwan., Shin JG; Department of Pharmacology and Pharmacogenomics Research Center, College of Medicine, Inje University, Busan, South Korea., Simon T; APHP, Saint Antoine Hospital, Paris, France., Fontana P; Geneva Platelet Group, University of Geneva School of Medicine, Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland., Giusti B; Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy., Geisler T; Department of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany., Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan., Trenk D; Department of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany., Siller-Matula JM; Department of Cardiology, Medical University of Vienna, Vienna, Austria., Ten Berg JM; St Antonius Center for Platelet Function Research, Department of Cardiology, St Antonius Hospital Nieuwegein, the Netherlands., Gurbel PA; Inova Center for Thrombosis Research and Drug Development. Inova Heart and Vascular Institute, Falls Church, VA, USA., Hulot JS; Sorbonne Universités, UPMC Univ Paris 06, Institute of Cardiometabolism and Nutrition (ICAN), Pitié-Salpêtrière Hospital, F-75013 Paris, France., Mitchell BD; Department of Medicine, University of Maryland, Baltimore, MD, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, MD., Schwab M; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany; Department of Clinical Pharmacology, University Hospital, Tübingen, Germany., Ritchie MD; Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA., Klein TE; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA., Shuldiner AR; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: ashuldin@som.umaryland.edu.
Corporate Authors: ICPC Investigators
Source: American heart journal [Am Heart J] 2018 Apr; Vol. 198, pp. 152-159. Date of Electronic Publication: 2017 Dec 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).
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  Data: <searchLink fieldCode="AU" term="%22Bergmeijer+TO%22">Bergmeijer TO</searchLink>; St Antonius Center for Platelet Function Research, Department of Cardiology, St Antonius Hospital Nieuwegein, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Reny+JL%22">Reny JL</searchLink>; Internal Medicine, Béziers Hospital, France, Geneva Platelet Group, University of Geneva School of Medicine, Department of Internal Medicine, Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pakyz+RE%22">Pakyz RE</searchLink>; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gong+L%22">Gong L</searchLink>; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+JP%22">Lewis JP</searchLink>; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kim+EY%22">Kim EY</searchLink>; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea.<br /><searchLink fieldCode="AU" term="%22Aradi+D%22">Aradi D</searchLink>; Heart Center Balatonfüred and Heart and Vascular Center, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Fernandez-Cadenas+I%22">Fernandez-Cadenas I</searchLink>; Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Neurovascular Research Laboratory, Valle d'Hebron Hebron Institute of Research, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Horenstein+RB%22">Horenstein RB</searchLink>; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lee+MTM%22">Lee MTM</searchLink>; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Whaley+RM%22">Whaley RM</searchLink>; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Montaner+J%22">Montaner J</searchLink>; Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gensini+GF%22">Gensini GF</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Cleator+JH%22">Cleator JH</searchLink>; Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chang+K%22">Chang K</searchLink>; Cardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Holmvang+L%22">Holmvang L</searchLink>; Department of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hochholzer+W%22">Hochholzer W</searchLink>; University Heart Center Freiburg, Bad Krozingen, Department of Cardiology and Angiology II, Bad Krozingen, Germany.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Winter+S%22">Winter S</searchLink>; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Altman+RB%22">Altman RB</searchLink>; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA; Departments of Bioengineering and Genetics, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alexopoulos+D%22">Alexopoulos D</searchLink>; Department of Cardiology, Patras University Hospital, Patras, Greece.<br /><searchLink fieldCode="AU" term="%22Kim+HS%22">Kim HS</searchLink>; Department of Pharmacology and Pharmacogenomics Research Center, College of Medicine, Inje University, Busan, South Korea.<br /><searchLink fieldCode="AU" term="%22Déry+JP%22">Déry JP</searchLink>; Quebec Heart and Lung Institute, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Gawaz+M%22">Gawaz M</searchLink>; Department of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Bliden+K%22">Bliden K</searchLink>; Inova Center for Thrombosis Research and Drug Development. 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