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Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.

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Title: Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Authors: Parthasarathy S; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States. Electronic address: shakthisarav@gmail.com., Henry K; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Pei H; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Clayton J; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Rempala M; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Johns D; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., De Frutos O; Lilly S.A., Avda.de la Industria 30, 28108 Alcobendas, Madrid, Spain., Garcia P; Lilly S.A., Avda.de la Industria 30, 28108 Alcobendas, Madrid, Spain., Mateos C; Lilly S.A., Avda.de la Industria 30, 28108 Alcobendas, Madrid, Spain., Pleite S; Lilly S.A., Avda.de la Industria 30, 28108 Alcobendas, Madrid, Spain., Wang Y; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Stout S; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Condon B; Lilly Research Laboratories, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, United States., Ashok S; Lilly Research Laboratories, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, United States., Lu Z; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Ehlhardt W; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Raub T; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Lai M; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Geeganage S; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States., Burkholder TP; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Jun 01; Vol. 28 (10), pp. 1887-1891. Date of Electronic Publication: 2018 Apr 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
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  Data: <searchLink fieldCode="AU" term="%22Parthasarathy+S%22">Parthasarathy S</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States. Electronic address: shakthisarav@gmail.com.<br /><searchLink fieldCode="AU" term="%22Henry+K%22">Henry K</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Pei+H%22">Pei H</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Clayton+J%22">Clayton J</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Rempala+M%22">Rempala M</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Johns+D%22">Johns D</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22De+Frutos+O%22">De Frutos O</searchLink>; Lilly S.A., Avda.de la Industria 30, 28108 Alcobendas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia+P%22">Garcia P</searchLink>; Lilly S.A., Avda.de la Industria 30, 28108 Alcobendas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Mateos+C%22">Mateos C</searchLink>; Lilly S.A., Avda.de la Industria 30, 28108 Alcobendas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pleite+S%22">Pleite S</searchLink>; Lilly S.A., Avda.de la Industria 30, 28108 Alcobendas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Stout+S%22">Stout S</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Condon+B%22">Condon B</searchLink>; Lilly Research Laboratories, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ashok+S%22">Ashok S</searchLink>; Lilly Research Laboratories, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Lu+Z%22">Lu Z</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Ehlhardt+W%22">Ehlhardt W</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Raub+T%22">Raub T</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Lai+M%22">Lai M</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Geeganage+S%22">Geeganage S</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.<br /><searchLink fieldCode="AU" term="%22Burkholder+TP%22">Burkholder TP</searchLink>; Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285-0150, United States.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2018 Jun 01; Vol. 28 (10), pp. 1887-1891. <i>Date of Electronic Publication: </i>2018 Apr 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bmcl.2018.03.092
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