Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

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Title: Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
Authors: Ostrom QT; Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.; Department of Population and Quantitative Heath Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America., Kinnersley B; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom., Wrensch MR; Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California, United States of America., Eckel-Passow JE; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America., Armstrong G; Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America., Rice T; Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California, United States of America., Chen Y; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America., Wiencke JK; Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California, United States of America., McCoy LS; Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California, United States of America., Hansen HM; Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California, United States of America., Amos CI; Institute for Clinical and Translational Research, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America., Bernstein JL; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America., Claus EB; School of Public Health, Yale University, New Haven, Connecticut, United States of America.; Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Il'yasova D; Department of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, Georgia, United States of America.; Cancer Control and Prevention Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Johansen C; Oncology clinic, Finsen Center, Rigshospitalet, Copenhagen, Denmark.; Survivorship Research Unit, The Danish Cancer Society Research Center, Copenhagen, Denmark., Lachance DH; Department of Neurology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America., Lai RK; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Merrell RT; Department of Neurology, NorthShore University HealthSystem, Evanston, Illinois, United States of America., Olson SH; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America., Sadetzki S; Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Schildkraut JM; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America., Shete S; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America., Rubin JB; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri, United States of America., Lathia JD; Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America., Berens ME; Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America., Andersson U; Department of Radiation Sciences, Faculty of Medicine, Umeå University, Umeå, Sweden., Rajaraman P; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America.; Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc, Gaithersburg, Maryland, United States of America., Linet MS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America., Wang Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America.; Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc, Gaithersburg, Maryland, United States of America., Yeager M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America.; Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc, Gaithersburg, Maryland, United States of America., Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom., Jenkins RB; Department of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America., Melin B; Department of Radiation Sciences, Faculty of Medicine, Umeå University, Umeå, Sweden., Bondy ML; Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America., Barnholtz-Sloan JS; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America. jsb42@case.edu.
Corporate Authors: GliomaScan consortium
Source: Scientific reports [Sci Rep] 2018 May 09; Vol. 8 (1), pp. 7352. Date of Electronic Publication: 2018 May 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
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