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Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

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Title: Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.
Authors: Robinson AR; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Yousefzadeh MJ; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Rozgaja TA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Wang J; Department of Chemistry, University of California, Riverside, CA 92521, USA., Li X; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Tilstra JS; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Feldman CH; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA., Gregg SQ; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Johnson CH; The Scripps Research Institute California, La Jolla, CA 92037, USA., Skoda EM; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Frantz MC; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Bell-Temin H; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Pope-Varsalona H; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, USA., Gurkar AU; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Nasto LA; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Paediatric Orthopaedics, G. Gaslini Children's Hospital, Genoa, Italy., Robinson RAS; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Fuhrmann-Stroissnigg H; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Czerwinska J; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland., McGowan SJ; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Cantu-Medellin N; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA., Harris JB; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Maniar S; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Ross MA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Trussoni CE; Division of Gastroenterology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA., LaRusso NF; Division of Gastroenterology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA., Cifuentes-Pagano E; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Pagano PJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Tudek B; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland., Vo NV; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA., Rigatti LH; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA., Opresko PL; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, USA., Stolz DB; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Watkins SC; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Burd CE; Department of Molecular Genetics, Cancer Biology and Genetics, The Ohio State University, Columbus OH 43210 USA., Croix CMS; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Siuzdak G; The Scripps Research Institute California, La Jolla, CA 92037, USA., Yates NA; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Biomedical Mass Spectrometry Center, Schools of the Health Sciences University of Pittsburgh, Pittsburgh, PA 15213, USA., Robbins PD; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA., Wang Y; Department of Chemistry, University of California, Riverside, CA 92521, USA., Wipf P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Kelley EE; Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV 26506, USA. Electronic address: eric.kelley@hsc.wvu.edu., Niedernhofer LJ; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: lniedern@scripps.edu.
Source: Redox biology [Redox Biol] 2018 Jul; Vol. 17, pp. 259-273. Date of Electronic Publication: 2018 Apr 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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