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Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.

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Title: Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
Authors: Khawaja AP; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK., Cooke Bailey JN; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Simcoe M; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK.; Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK., Igo RP Jr; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Song YE; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Wojciechowski R; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Johns Hopkins Wilmer Eye Institute, Baltimore, MD, USA., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye-ACP), Duke-NUS Medical School, Singapore, Singapore., Khaw PT; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Pasquale LR; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA., Haines JL; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Foster PJ; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.; Division of Genetics and Epidemiology, UCL Institute of Ophthalmology, London, UK., Wiggs JL; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. janey_wiggs@meei.harvard.edu., Hammond CJ; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK. chris.hammond@kcl.ac.uk., Hysi PG; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK. pirro.hysi@kcl.ac.uk.; Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK. pirro.hysi@kcl.ac.uk.
Corporate Authors: UK Biobank Eye and Vision Consortium, NEIGHBORHOOD Consortium
Source: Nature genetics [Nat Genet] 2018 Jun; Vol. 50 (6), pp. 778-782. Date of Electronic Publication: 2018 May 21.
Publication Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
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  Data: <searchLink fieldCode="AU" term="%22Khawaja+AP%22">Khawaja AP</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cooke+Bailey+JN%22">Cooke Bailey JN</searchLink>; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Wareham+NJ%22">Wareham NJ</searchLink>; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Scott+RA%22">Scott RA</searchLink>; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Simcoe+M%22">Simcoe M</searchLink>; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK.; Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Igo+RP+Jr%22">Igo RP Jr</searchLink>; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Song+YE%22">Song YE</searchLink>; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Wojciechowski+R%22">Wojciechowski R</searchLink>; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Johns Hopkins Wilmer Eye Institute, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye-ACP), Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Khaw+PT%22">Khaw PT</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22Pasquale+LR%22">Pasquale LR</searchLink>; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haines+JL%22">Haines JL</searchLink>; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Foster+PJ%22">Foster PJ</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.; Division of Genetics and Epidemiology, UCL Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22Wiggs+JL%22">Wiggs JL</searchLink>; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. janey_wiggs@meei.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Hammond+CJ%22">Hammond CJ</searchLink>; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK. chris.hammond@kcl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Hysi+PG%22">Hysi PG</searchLink>; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK. pirro.hysi@kcl.ac.uk.; Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK. pirro.hysi@kcl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2018 Jun; Vol. 50 (6), pp. 778-782. <i>Date of Electronic Publication: </i>2018 May 21.
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