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Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice.

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Title: Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice.
Authors: Zhuang GZ; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA., Upadhyay U; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA., Tong X; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA., Kang Y; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA., Erasso DM; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA., Fu ES; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA., Sarantopoulos KD; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Martin ER; John T. MacDonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Wiltshire T; Department of Pharmacology and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Diatchenko L; Alan Edwards Centre for Research on Pain, Department of Anesthesiology, McGill University, Montreal, Quebec, Canada., Smith SB; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA., Maixner W; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA., Levitt RC; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA. rlevitt@med.miami.edu.; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. rlevitt@med.miami.edu.; John T. MacDonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA. rlevitt@med.miami.edu.; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. rlevitt@med.miami.edu.
Source: Gene therapy [Gene Ther] 2018 Jul; Vol. 25 (4), pp. 297-311. Date of Electronic Publication: 2018 Apr 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice.
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  Data: <searchLink fieldCode="AU" term="%22Zhuang+GZ%22">Zhuang GZ</searchLink>; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Upadhyay+U%22">Upadhyay U</searchLink>; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Tong+X%22">Tong X</searchLink>; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kang+Y%22">Kang Y</searchLink>; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Erasso+DM%22">Erasso DM</searchLink>; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Fu+ES%22">Fu ES</searchLink>; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Sarantopoulos+KD%22">Sarantopoulos KD</searchLink>; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Martin+ER%22">Martin ER</searchLink>; John T. MacDonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Wiltshire+T%22">Wiltshire T</searchLink>; Department of Pharmacology and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Diatchenko+L%22">Diatchenko L</searchLink>; Alan Edwards Centre for Research on Pain, Department of Anesthesiology, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Smith+SB%22">Smith SB</searchLink>; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Maixner+W%22">Maixner W</searchLink>; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Levitt+RC%22">Levitt RC</searchLink>; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA. rlevitt@med.miami.edu.; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. rlevitt@med.miami.edu.; John T. MacDonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA. rlevitt@med.miami.edu.; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. rlevitt@med.miami.edu.
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