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Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates.

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Title: Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates.
Authors: Girard L; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada., Birse K; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada., Holm JB; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA., Gajer P; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA., Humphrys MS; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA., Garber D; Laboratory Branch, Division of HIV/AIDS Prevention, National Centre for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Disease and Tuberculosis Prevention, CDC, Atlanta, USA., Guenthner P; Laboratory Branch, Division of HIV/AIDS Prevention, National Centre for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Disease and Tuberculosis Prevention, CDC, Atlanta, USA., Noël-Romas L; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada., Abou M; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada., McCorrister S; Mass Spectrometry and Proteomics Core Facility, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada., Westmacott G; Mass Spectrometry and Proteomics Core Facility, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada., Wang L; Magee Women's Research Institute, Pittsburgh, USA.; School of Pharmacy, University of Pittsburgh, Pittsburgh, USA., Rohan LC; Magee Women's Research Institute, Pittsburgh, USA.; School of Pharmacy, University of Pittsburgh, Pittsburgh, USA., Matoba N; Center for Predictive Medicine, University of Louisville, Louisville, USA.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, USA.; James Graham Brown Cancer Centre, University of Louisville, Louisville, USA., McNicholl J; Laboratory Branch, Division of HIV/AIDS Prevention, National Centre for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Disease and Tuberculosis Prevention, CDC, Atlanta, USA., Palmer KE; Center for Predictive Medicine, University of Louisville, Louisville, USA.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, USA.; James Graham Brown Cancer Centre, University of Louisville, Louisville, USA., Ravel J; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA., Burgener AD; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada. Adam.Burgener@umanitoba.ca.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada. Adam.Burgener@umanitoba.ca.; Unit of Infectious Diseases, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. Adam.Burgener@umanitoba.ca.
Source: Scientific reports [Sci Rep] 2018 May 23; Vol. 8 (1), pp. 8059. Date of Electronic Publication: 2018 May 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates.
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  Data: <searchLink fieldCode="AU" term="%22Girard+L%22">Girard L</searchLink>; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Birse+K%22">Birse K</searchLink>; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Holm+JB%22">Holm JB</searchLink>; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA.<br /><searchLink fieldCode="AU" term="%22Gajer+P%22">Gajer P</searchLink>; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA.<br /><searchLink fieldCode="AU" term="%22Humphrys+MS%22">Humphrys MS</searchLink>; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA.<br /><searchLink fieldCode="AU" term="%22Garber+D%22">Garber D</searchLink>; Laboratory Branch, Division of HIV/AIDS Prevention, National Centre for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Disease and Tuberculosis Prevention, CDC, Atlanta, USA.<br /><searchLink fieldCode="AU" term="%22Guenthner+P%22">Guenthner P</searchLink>; Laboratory Branch, Division of HIV/AIDS Prevention, National Centre for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Disease and Tuberculosis Prevention, CDC, Atlanta, USA.<br /><searchLink fieldCode="AU" term="%22Noël-Romas+L%22">Noël-Romas L</searchLink>; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Abou+M%22">Abou M</searchLink>; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22McCorrister+S%22">McCorrister S</searchLink>; Mass Spectrometry and Proteomics Core Facility, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Westmacott+G%22">Westmacott G</searchLink>; Mass Spectrometry and Proteomics Core Facility, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Magee Women's Research Institute, Pittsburgh, USA.; School of Pharmacy, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Rohan+LC%22">Rohan LC</searchLink>; Magee Women's Research Institute, Pittsburgh, USA.; School of Pharmacy, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Matoba+N%22">Matoba N</searchLink>; Center for Predictive Medicine, University of Louisville, Louisville, USA.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, USA.; James Graham Brown Cancer Centre, University of Louisville, Louisville, USA.<br /><searchLink fieldCode="AU" term="%22McNicholl+J%22">McNicholl J</searchLink>; Laboratory Branch, Division of HIV/AIDS Prevention, National Centre for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Disease and Tuberculosis Prevention, CDC, Atlanta, USA.<br /><searchLink fieldCode="AU" term="%22Palmer+KE%22">Palmer KE</searchLink>; Center for Predictive Medicine, University of Louisville, Louisville, USA.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, USA.; James Graham Brown Cancer Centre, University of Louisville, Louisville, USA.<br /><searchLink fieldCode="AU" term="%22Ravel+J%22">Ravel J</searchLink>; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA.<br /><searchLink fieldCode="AU" term="%22Burgener+AD%22">Burgener AD</searchLink>; National HIV and Retrovirology Labs, JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada. Adam.Burgener@umanitoba.ca.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada. Adam.Burgener@umanitoba.ca.; Unit of Infectious Diseases, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. Adam.Burgener@umanitoba.ca.
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