RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.
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| Title: | RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection. |
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| Authors: | Ates LS; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Sayes F; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Frigui W; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Ummels R; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands., Damen MPM; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands., Bottai D; University of Pisa, Department of Biology, Pisa, Italy., Behr MA; McGill International TB Centre, Infectious Diseases and Immunity in Global Health Program at the McGill University Health Centre Research Institute, Montreal, Canada., van Heijst JWJ; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Bitter W; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands., Majlessi L; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Brosch R; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France. |
| Source: | PLoS pathogens [PLoS Pathog] 2018 Jun 18; Vol. 14 (6), pp. e1007139. Date of Electronic Publication: 2018 Jun 18 (Print Publication: 2018). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1553-7374 |
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| DOI: | 10.1371/journal.ppat.1007139 |
