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RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.

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Title: RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.
Authors: Ates LS; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Sayes F; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Frigui W; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Ummels R; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands., Damen MPM; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands., Bottai D; University of Pisa, Department of Biology, Pisa, Italy., Behr MA; McGill International TB Centre, Infectious Diseases and Immunity in Global Health Program at the McGill University Health Centre Research Institute, Montreal, Canada., van Heijst JWJ; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Bitter W; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands., Majlessi L; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Brosch R; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.
Source: PLoS pathogens [PLoS Pathog] 2018 Jun 18; Vol. 14 (6), pp. e1007139. Date of Electronic Publication: 2018 Jun 18 (Print Publication: 2018).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.
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  Data: <searchLink fieldCode="AU" term="%22Ates+LS%22">Ates LS</searchLink>; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sayes+F%22">Sayes F</searchLink>; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.<br /><searchLink fieldCode="AU" term="%22Frigui+W%22">Frigui W</searchLink>; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ummels+R%22">Ummels R</searchLink>; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Damen+MPM%22">Damen MPM</searchLink>; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bottai+D%22">Bottai D</searchLink>; University of Pisa, Department of Biology, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Behr+MA%22">Behr MA</searchLink>; McGill International TB Centre, Infectious Diseases and Immunity in Global Health Program at the McGill University Health Centre Research Institute, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22van+Heijst+JWJ%22">van Heijst JWJ</searchLink>; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bitter+W%22">Bitter W</searchLink>; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Majlessi+L%22">Majlessi L</searchLink>; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.<br /><searchLink fieldCode="AU" term="%22Brosch+R%22">Brosch R</searchLink>; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2018 Jun 18; Vol. 14 (6), pp. e1007139. <i>Date of Electronic Publication: </i>2018 Jun 18 (<i>Print Publication: </i>2018).
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