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Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.

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Title: Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
Authors: Cleghorn LAT; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Ray PC; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Odingo J; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States., Kumar A; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States., Wescott H; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States., Korkegian A; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States., Masquelin T; Eli Lilly and Company, Discovery Chemistry Research, Lilly Corporate Centre , MC/87/02/203, G17, Indianapolis , Indiana 46285 , United States., Lopez Moure A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Wilson C; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Davis S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Huggett M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Turner P; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Smith A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Epemolu O; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Zuccotto F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Scullion P; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Shishikura Y; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Ferguson L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Rullas J; Diseases of the Developing World , GlaxoSmithKline , Calle Severo Ochoa 2 , 28760 Tres Cantos , Madrid Spain., Guijarro L; Diseases of the Developing World , GlaxoSmithKline , Calle Severo Ochoa 2 , 28760 Tres Cantos , Madrid Spain., Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Green SR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom., Hipskind P; Eli Lilly and Company, Discovery Chemistry Research, Lilly Corporate Centre , MC/87/02/203, G17, Indianapolis , Indiana 46285 , United States., Parish T; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States., Wyatt PG; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.
Source: Journal of medicinal chemistry [J Med Chem] 2018 Aug 09; Vol. 61 (15), pp. 6592-6608. Date of Electronic Publication: 2018 Jul 26.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
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  Data: <searchLink fieldCode="AU" term="%22Cleghorn+LAT%22">Cleghorn LAT</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ray+PC%22">Ray PC</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Odingo+J%22">Odingo J</searchLink>; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States.<br /><searchLink fieldCode="AU" term="%22Wescott+H%22">Wescott H</searchLink>; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States.<br /><searchLink fieldCode="AU" term="%22Korkegian+A%22">Korkegian A</searchLink>; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States.<br /><searchLink fieldCode="AU" term="%22Masquelin+T%22">Masquelin T</searchLink>; Eli Lilly and Company, Discovery Chemistry Research, Lilly Corporate Centre , MC/87/02/203, G17, Indianapolis , Indiana 46285 , United States.<br /><searchLink fieldCode="AU" term="%22Lopez+Moure+A%22">Lopez Moure A</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wilson+C%22">Wilson C</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Davis+S%22">Davis S</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Huggett+M%22">Huggett M</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Turner+P%22">Turner P</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Smith+A%22">Smith A</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Epemolu+O%22">Epemolu O</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zuccotto+F%22">Zuccotto F</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Riley+J%22">Riley J</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Scullion+P%22">Scullion P</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Shishikura+Y%22">Shishikura Y</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ferguson+L%22">Ferguson L</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rullas+J%22">Rullas J</searchLink>; Diseases of the Developing World , GlaxoSmithKline , Calle Severo Ochoa 2 , 28760 Tres Cantos , Madrid Spain.<br /><searchLink fieldCode="AU" term="%22Guijarro+L%22">Guijarro L</searchLink>; Diseases of the Developing World , GlaxoSmithKline , Calle Severo Ochoa 2 , 28760 Tres Cantos , Madrid Spain.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Green+SR%22">Green SR</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hipskind+P%22">Hipskind P</searchLink>; Eli Lilly and Company, Discovery Chemistry Research, Lilly Corporate Centre , MC/87/02/203, G17, Indianapolis , Indiana 46285 , United States.<br /><searchLink fieldCode="AU" term="%22Parish+T%22">Parish T</searchLink>; TB Discovery Research , Infectious Disease Research Institute (IDRI) , 1616 Eastlake Avenue East, Suite 400 , Seattle , Washington 98102 , United States.<br /><searchLink fieldCode="AU" term="%22Wyatt+PG%22">Wyatt PG</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee DD1 5EH , United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2018 Aug 09; Vol. 61 (15), pp. 6592-6608. <i>Date of Electronic Publication: </i>2018 Jul 26.
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