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Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.

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Title: Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.
Authors: Saenz-Ponce N; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia., Pillay R; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia., de Long LM; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia., Kashyap T; Karyopharm Therapeutics Inc., Newton, MA 02459, USA., Argueta C; Karyopharm Therapeutics Inc., Newton, MA 02459, USA., Landesman Y; Karyopharm Therapeutics Inc., Newton, MA 02459, USA., Hazar-Rethinam M; Massachusetts General Hospital Cancer Center, Harvard Medical School, MA 02114, USA., Boros S; Department of Pathology, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia., Panizza B; Department of Ear Nose and Throat, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.; School of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia., Jacquemyn M; Katholieke Universiteit Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Herestraat 49, 3000 Leuven, Belgium., Daelemans D; Katholieke Universiteit Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Herestraat 49, 3000 Leuven, Belgium., Gannon OM; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia., Saunders NA; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia. nsaunders@uq.edu.au.
Source: Science translational medicine [Sci Transl Med] 2018 Jun 27; Vol. 10 (447).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.
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  Data: <searchLink fieldCode="AU" term="%22Saenz-Ponce+N%22">Saenz-Ponce N</searchLink>; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Pillay+R%22">Pillay R</searchLink>; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia.<br /><searchLink fieldCode="AU" term="%22de+Long+LM%22">de Long LM</searchLink>; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Kashyap+T%22">Kashyap T</searchLink>; Karyopharm Therapeutics Inc., Newton, MA 02459, USA.<br /><searchLink fieldCode="AU" term="%22Argueta+C%22">Argueta C</searchLink>; Karyopharm Therapeutics Inc., Newton, MA 02459, USA.<br /><searchLink fieldCode="AU" term="%22Landesman+Y%22">Landesman Y</searchLink>; Karyopharm Therapeutics Inc., Newton, MA 02459, USA.<br /><searchLink fieldCode="AU" term="%22Hazar-Rethinam+M%22">Hazar-Rethinam M</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Boros+S%22">Boros S</searchLink>; Department of Pathology, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Panizza+B%22">Panizza B</searchLink>; Department of Ear Nose and Throat, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.; School of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Jacquemyn+M%22">Jacquemyn M</searchLink>; Katholieke Universiteit Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Herestraat 49, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Daelemans+D%22">Daelemans D</searchLink>; Katholieke Universiteit Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Herestraat 49, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Gannon+OM%22">Gannon OM</searchLink>; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Saunders+NA%22">Saunders NA</searchLink>; Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia. nsaunders@uq.edu.au.
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