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The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.

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Title: The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.
Authors: Zhang Y; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Burberry A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Wang JY; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Sandoe J; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Ghosh S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Udeshi ND; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Svinkina T; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Mordes DA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Mok J; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Charlton M; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Li QZ; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Carr SA; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Eggan K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.
Source: Genes & development [Genes Dev] 2018 Jul 01; Vol. 32 (13-14), pp. 929-943. Date of Electronic Publication: 2018 Jun 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE
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  Data: The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Burberry+A%22">Burberry A</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Wang+JY%22">Wang JY</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Sandoe+J%22">Sandoe J</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+S%22">Ghosh S</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Udeshi+ND%22">Udeshi ND</searchLink>; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Svinkina+T%22">Svinkina T</searchLink>; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Mordes+DA%22">Mordes DA</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.<br /><searchLink fieldCode="AU" term="%22Mok+J%22">Mok J</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Charlton+M%22">Charlton M</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Li+QZ%22">Li QZ</searchLink>; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.<br /><searchLink fieldCode="AU" term="%22Carr+SA%22">Carr SA</searchLink>; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.<br /><searchLink fieldCode="AU" term="%22Eggan+K%22">Eggan K</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.
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        Value: 10.1101/gad.313932.118
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