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PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.

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Title: PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.
Authors: McNeill RS; Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Stroobant EE; Department of Chemistry, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Smithberger E; Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Canoutas DA; Department of Biology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Butler MK; Department of Biology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Shelton AK; Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Patel SD; Department of Chemistry, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Limas JC; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Skinner KR; Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Bash RE; Departments of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Schmid RS; Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Miller CR; Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Departments of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.
Source: PloS one [PLoS One] 2018 Jul 05; Vol. 13 (7), pp. e0200014. Date of Electronic Publication: 2018 Jul 05 (Print Publication: 2018).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.
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  Data: <searchLink fieldCode="AU" term="%22McNeill+RS%22">McNeill RS</searchLink>; Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Stroobant+EE%22">Stroobant EE</searchLink>; Department of Chemistry, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Smithberger+E%22">Smithberger E</searchLink>; Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Canoutas+DA%22">Canoutas DA</searchLink>; Department of Biology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Butler+MK%22">Butler MK</searchLink>; Department of Biology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Shelton+AK%22">Shelton AK</searchLink>; Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Patel+SD%22">Patel SD</searchLink>; Department of Chemistry, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Limas+JC%22">Limas JC</searchLink>; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Skinner+KR%22">Skinner KR</searchLink>; Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Bash+RE%22">Bash RE</searchLink>; Departments of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Schmid+RS%22">Schmid RS</searchLink>; Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Miller+CR%22">Miller CR</searchLink>; Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Departments of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.; Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.
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